respiratory Flashcards
shunt vs dead space
shunt is air passing through lungs without participating in gas exchange
dead space is is volume of gas not participating in gas exchange due to ventilation without perfusion
what is oxygen hemoglobin disassociation curve
shows percent saturation of hemoglobin at various partial pressures of oxygen.
which way does curve shift in alkalosis?
left
which way does the curve go in acidosis
right
in acidosis, does hemoglobin have higher or lower affinity for O2?
lower
in acidosis, does hemoglobin have higher or lower affinity for O2?
lower
In alkalosis, does hemoglobin have higher or lower affinity for O2
higher
Bohr effect
in acidosis state, hemoglobin has lower affinity for O2 resulting in dumping. causes curve to shift down and to the right.
in alkalosis, hemoglobin has higher affinity for O2 causing curve to shift up and to the left.
malignant hyperthermia
uncontrolled release of intracellular calcium in skeletal muscle
sustained muscle contractions
elevated ATP causes hypermetabolic state, Increased oxygen consumption and CO2 production
causes lactic acidosis, hyperthermia, hypertension, mottled cyanosis, arrhythmia
elevated potassium and magnesium
later AKI, DIC, liver failure, cerebral edema seizures
what is a normal tidal volume?
500cc
which parts of the brain controls breathing?
brain stem, medulla oblongata and pons
what is dead space ventilation?
volume in airways and lungs that does not participate in gas exchange
what is mechanical dead space
artificial airways and ventilator circuits
how much space does physiological dead space account for?
alveolar and anotomic dead space accounts for approx 30% of total ventilation
2 main atmospheric gases of volume of air
nitrogen 78%
oxygen 21% = 760mmHg at sea level