Respiratory Flashcards
Hypoxemia
Partial pressure of oxygen less than 80 mmHg or arterial blood hemoglobin saturation of less than 95%
Three causes of hypoxemia
- Low inspired oxygen concentration
- Hypoventilation
- Venus admixture
Venous admixture
- Low ventilation perfusion regions (severe, diffuse lung disease- edema, pneumonia, hemorrhage)
- Small airway and alveolar collapse or infiltration (atelectasis, no V/Q regions - edema, pneumonia, hemorrhage)
- Diffusion defects (moderate to severe diffuse lung disease- oxygen toxicity, smoke inhalation, ARDS)
- Anatomic right to left shunts (Right to left PDA and VSD, intrapulmonary AV and atomic shunts)
PaO2
Partial pressure of oxygen dissolved in the plasma of arterial blood.
Arterial PaO2 is a measure of the ability of lungs to move oxygen from the atmosphere to the blood.
Normal PaO2 at sea level
80-110 mmHg
SaO2
Hemoglobin saturation with oxygen
SO2/PO2 relationship
Described by the sigmoid shaped oxygen hemoglobin dissociation curve
Main takeaway:
Normoxemia and hypoxemia are only a few saturation points away from each other
Hypoventilation
An elevated PaCO2 or one of its surrogate markers (ETCO2, PCO2)
PCO2
Central Venus PCO2 is usually about 5 mmHg higher than PaCO2
Alveolar oxygen
Balance between the amount of oxygen being delivered to the alveoli and the amount of oxygen being removed from the alveoli
PAO2
Partial pressure of alveolar oxygen
Can be determined by the alveolar air equation
Venous admixture
All the ways in which Venus blood can get from the right side to the left side of circulation without being properly oxygenated
Alveolar air equation
PAO2 = Fio2*(Patm - PH2O) - (PaCO2/RQ)
Rule of 120
PaCO2 + PaO2 = 120
Can determine the presence of venous admixture
Must be done on room air
Normal PaCO2 = 40, PaO2 = 80
5 causes of hypoxia
-low FiO2
-hypoventilation
-shunts
-diffusion impairment
-V/Q mismatch