Respiratory Flashcards
What type of hypersensitivity reaction is asthma?
Type I (IgE)
What type of hypersensitivity reaction is Goodpasture’s disease?
Type II (IgG)
What type of hypersensitivity reaction is SLE?
Type III (immune complex formation)
What type of hypersensitivity reaction is TB?
Type 4 (cell mediated)
What is a type I hypersensitivity reaction?
Reaction mediated by IgE antibodies.
(Allergy) ie anaphylaxis
What is type II hypersensitivity?
Cytotoxic reaction mediated by IgG or IgM antibodies.
(antibody binds to host cell which is perceived to be foreign destruction)
Goodpastures, Graves, Myasthenia Gravis
What is type III hypersensitivity?
Reaction mediated by immune complexes – deposited in vessel walls.
RA, post-strep glomerulonephritis, reactive arthritis, SLE
What is type IV hypersensitivity?
Delayed reaction mediated by cellular response.
Cytotoxic, cell-mediated.
T helper cell activated by antigen presenting cells.
Antigen presented again in the future causes inflammatory response.
Contact dermatitis, Mantoux test, MS, coeliac
What happens in type I hypersensitivity?
IgE mediated, mast cell degranulation, antibody binding to antigen eg asthma, allergy
What happens in type II hypersensitivity?
IgG reaction – cytotoxic – IgG binds to cell and kills its – Rhesus haemolytic disease, Goodpastures,
What happens in type III hypersensitivity
Immune complex forms (soluble but saturates) – SLE, EAA
What happens in type IV hypersensitivity?
Cell mediated delayed (CD-4 cells are sensitized to infection but cant clear it - granuloma) – TB, sarcoid, Wegeners,
What is total lung capacity?
(5900ml): max volume of air/gas the lungs can contain/accommodate
What is vital capacity?
(4700ml): amount of effort that can be exhaled with max effort after max inspiration
What is tidal volume?
(500ml): Volume of air inspired (inhaled) and expired (exhaled) in a normal breath
What is inspiratory capacity?
(3500ml): max volume of air that can be inhaled after normal tidal expiration
What is expiratory reserve volume?
(1200ml): Volume of air exceeding tidal expiration that can be exhaled with max effort
What is inspiratory reserve volume?
(3000ml): Volume of air exceeding tidal inspiration that can be inhaled with max effort
What is functional residual capacity?
(2400ml): Volume of air remaining in the lungs after a normal tidal expiration
What is residual volume?
(1200ml): Volume of air that remains in lungs after expiration (keeps alveoli inflated)
What is FEV?
How much air a person can exhale during a forced breath
What is FEV1?
FEV in 1 second
What is FVC?
Total volume of air forcefully exhaled during FEV test
What is peak expiratory flow rate (PEFR)?
The peak flow rate during expiration