GI Flashcards
What are the key GI symptoms?
- Abdominal pain
- Diarrhoea
- Constipation
- PR bleeding
- Vomiting
- Weight loss
- Fatigue
- Dyspepsia
- Dysphagia
How is the abdomen divided?

What does pain in each division of the abdomen indicate?

What is IBD?
Inflammation in part of the GI tract due to an autoimmune reaction
•2 conditions : ulcerative colitis and crohn’s disease
What causes IBD?
Abnormal autoimmune reaction
What are the risk factors for IBD?
- Crohn’s : smoking and family history
- UC : family history
How is IBD investigated?
Bloods
CRP (will be raised due to active inflammation)
Faecal calprotectin = SCREENING TEST
Colonoscopy with biopsy = DIAGNOSTIC
What is Crohn’s disease?
transmural inflammation of ANY part of the GI tract (mouth-anus).
What is a risk factor for Crohn’s disease?
SMOKING.
What is the pathophysiology of Crohn’s?
Inflammation is NOT continuous -> creates skip lesions. Discrete areas of inflammation throughout the colon.
What are the symptoms of Crohn’s?
Polyarticular arthritis
Erythema nodosum
Aphthous mouth ulcers
Episcleritis
Generalised abdominal pain
Diarrhoea
Non specific -> fatigue, malaise, anorexia, weight loss
How is Crohn’s managed?
- Inducing remission -> 1st line are steroids (e.g. prednisolone)
- DMARDS such azathioprine or methotrexate
- Maintaining remission -> 1st line are DMARDS such as azathioprine or mercaptopurine
- 2nd line is methotrexate
- If neither work start introducing biological medications such as infliximab or adalimumab
What is ulcerative colitis?
Continuous, superficial inflammation limited to the rectum and the colon.
What is a protective factor for ulcerative colitis?
Smoking
What is the pathophysiology of ulcerative colitis?
Inflammation is limited the intestinal mucosa
What are the symptoms of ulcerative colitis?
BLOODY diarrhoea
Faecal urgency
Tenesmus
Generalised abdominal pain
PRIMARY SCLEROSING CHOLANGITIS
The rest are identical to Crohn’s
How is ulcerative colitis managed?
- Inducing remission -> 1st line aminosalicylate (e.g. mesalazine)
- 2nd line corticosteroids (e.g. prednisolone)
- 3rd line addition of calcineurin inhibitors if needed (e.g. ciclosporin)
- Maintaining remission
- Aminosalicylate
- Azathioprine
Mercaptopurine
Surgery for UC can be curative due to the limited effect in the rectum and colon -> panproctocolectomy
What are the key features of Crohn’s?
Crows NESTS
- N : no blood or mucus
- E : entire GI tract
- S : skip lesions on endoscopy
- T : TERMINAL ileum most affected and TRANSMURAL inflammation
- S : smoking is a risk factor
What are the key features of ulcerative colitis?
- CLOSEUP
- C : continuous inflammation
- L : limited to the colon and the rectum
- O : only the superficial mucosa is affected
- S : smoking is protective
- E : excrete blood and mucus
- U : use aminosalicylates
- P : primary sclerosing cholangitis
What is IBS?
FUNCTIONAL bowel disorder causing recurrent abdominal pain with abnormal bowel motility causing constipation and/or diarrhoea
What are the symptoms of IBS?
- A : Abdominal pain RELIEVED BY DEFECATION
- B : Bloating
- C : Change in bowel habit (constipation and/or diarrhoea)
How is IBS investigated?
Bloods (including coeliac serology and CRP for inflammation).
Faecal calprotectin
Colonoscopy
How is IBS treated?
Diet modification
For diarrhea: loperamide
For constipation: soluble fibers and laxatives
For spasms and pain: anti-spasmodics
What is Coeliac disease?
Chronic autoimmune condition where exposure to gluten causing inflammation within the small bowel