Respiration I Flashcards

1
Q

What is laminar flow

A

flow of a fluid when each particle follows a smooth path

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2
Q

What is flow type governed

A

determination of flow type

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3
Q

Describe the alveolar pressure during expiration

A

alveolar pressure is greater than atmospheric pressure

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4
Q

Under laminar conditions what is flow rate proportional to

A

the pressure gradient

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5
Q

Where does maximum rate of flow occur

A

centre of a tube

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6
Q

What is turbulent flow rate proportional to

A

square root of the pressure gradient/difference

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7
Q

TRUE or FALSE - in most places of the lung air flow is laminar

A

FALSE

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8
Q

What do you need to achieve a set flow rate under turbulent conditions

A

greater pressure gradient

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9
Q

Describe the relationship between flow rate and pressure under laminar conditions

A

positive linear correlation

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10
Q

Under what circumstances do eddies develop

A

when turbulent air hits branching points

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11
Q

Describe transitional flow

A

when air becomes turbulent then returns to being laminar

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12
Q

Where is cross sectional area of the airways high

A

respiratory zone

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13
Q

Why does the respiratory zone have high cross sectional area

A

branches

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14
Q

Describe the relationship between velocity and cross sectional area

A

velocity decreases as cross sectional area increases

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15
Q

What is the normal flow type at high velocity

A

turbulent

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16
Q

Name some factors reducing airway diameter

A

inflammation, increased mucous production, oedema

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17
Q

What is COPD

A

progressive lung diseases characterised by increased airway resistance and decreased airflow

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18
Q

Examples of COPD

A

Chronic bronchitis, emphysema

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19
Q

Describe chronic bronchitid

A

long term inflammation of bronchi and bronchioles

20
Q

Describe emphysema

A

destruction of alveoli walls

21
Q

True or False - There is a cure for emphysema

22
Q

What are gluco-corticosteroids used for

A

reduce background inflammation and maintain decent air flow

23
Q

Why do the airways become floppy in emphysema

A

loss of elastic nature

24
Q

What can be used to manage COPD

A

gluco-corticosteroids, and bronchodilators

25
What are bronchodilators
anti-cholinergics or B2 adrenoreceptor agonists
26
Example of beta 2 adrenoreceptor agonist
salbutamol
27
What is Poiseuille's law
Airway resistance is proportional to gas viscocity and the length of the tube
28
What is airway resistance inversely proportional to
fourth power of the radius
29
What is the difference in airway resistance in COPD
huge resistance in small airways compared to normal.
30
What is oedema
increased fluid retention in the lungs
31
Describe the pressure in the alveoli at the end of normal respiration
same as barometric pressure
32
describe the pressure in the intrapleural space at rest
sub atmospheric
33
What happens if alveolar and intrapleural pressure are equal
collapsed lung
34
What is transmural pressure
difference in pressure between two sides of a wall
35
Where is the maximum pressure gradient in the lungs during inspiration
alveoli
36
What is the net effect of the transmural pressure during inspiration
airway expansion
37
What is the value of transmural pressure during inspiration
positive
38
What is the effect of transmural pressure during inspiration
causes airway expansion, therefore decreasing the resistance
39
How can patients with emphysema overcome airway collapse
exhale through pursed lips or expire slowly
40
Describe the relationship between lung volume and airway resistance
as lung volume increases, airway resistance reduces
41
When is airway resistance highest
small lung volume
42
Describe the relationship between resistance and inflation
when resistance is increased inflation is impaired
43
Under what time constant do lungs inflate rapidly
small time constant
44
What is the time constant under normal conditions
low time constant
45
Describe the time constant in COPD
increased, lungs dont inflate as quickly