Respiration

Question 1

Chronic asthma treatment

Answer 1

1. SABA e.g. salbutamol
   
   2. Add an ICS alongside the SABA e.g. beclometosone, budesonide,
   3. Add a LABA e.g. formoterol or Salmaterol
   4. Increase dose of the ICS
   5. Add an LTRA e.g. monteleukast
   6. MART therapy e.g. ICS + LABA such as symbicort - budesonide/formoterol

Question 2

Mechanism of action glucocorticosteroids for asthma

Answer 2

• Binds to NR3C1 nuclear receptor
  
  • Switch of inflammatory genes
  • Activate anti-inflammatory genes