Hard

Question 1

How can we use different amorphous form to increase solubility of a poorly soluble drug (2)

Answer 1

• Amorphous forms have lower stability due to lack of range order
• This makes them more soluble and less stable = dissolve quicker

Question 2

Lipinskis rule of five

Answer 2

• MW less than 500
• Log P less than 5
• H donors less than 5
• H acceptors less than 10

Question 3

Two reasons why a drug is formulated as hydrochloride rather than as a base (2)

Answer 3

• Salt form enhances water solubility, making it easier to dissolve
• This improves extent of absorption
• HCL salt is more water soluble than bases which have poor solubility

Question 4

Describe three physiology factors which effect drug absorption

Answer 4

• Faster gastric emptying can enhance absorption but excessive motility like diarrhoea can reduce it
• Food can increase if its fatty, or it can delay it
• Other drugs may increase transit time (enhances absorption)

Question 5

Advantage and disadvantage of wet granulation

Answer 5

Question 6

Main difference between wet and dry granulation

Answer 6

Wet includes adding a wetting agent as well as drying after

Question 7

Advantages and disadvantage of granulation dry

Answer 7

Question 8

How does particle size effect drug properties

Answer 8

• Drug bioavailability (dissolution)
• Settling rate (suspensions)
• When making homogenous mixture e.g. if particles are different sizes its hard to mix evenly
• Flowability - powder flow is inversely proportional to particle size