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Spring 2020: P1 Therapeutics > Rescue Inhalers: Short Acting Anticholinergics > Flashcards

Rescue Inhalers: Short Acting Anticholinergics Flashcards

1
Q

How do short-acting anticholingergics work?

A

They competitively inhibit cholinergic receptors in bronchial smooth muscle, reducing cGMP and initiating bronchodilation.

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2
Q

What is the brand name for ipratropium HFA?

A

Atrovent

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3
Q

What dorm is ipratropium HFA available in?

A

Metered dose inhaler (MDI)

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4
Q

What age groups may ipratropium be used in?

A

Children and adults

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5
Q

What adverse effects are associated with ipratropium?

A
  • Dry mouth
  • Urinary retention
  • Infection
  • Sinusitis
  • Bronchitis
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6
Q

How is ipratropium used to treat asthma exacerbations?

A

Used in combination with albuterol

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7
Q

Give two clinical pearls for ipratropium.

A
  1. May be mixed in the same nebulizer with albuterol
  2. Should NOT be used as a first-line therapy; should be added to SABA therapy for severe exacerbations
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8
Q

What form is standard (non-HFA) ipratropium available in?

A

Nebulizer solution

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9
Q

What is the brand name for ipratropium/albuterol MDI?

A

Combivent Respimat

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10
Q

What form is Combivent Respimat available in?

A

Metered dose inhaler (MDI)

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11
Q

What dose is Combivent Respimat available in?

A

20 mcg/inhalation ipratropium & 100 mcg/inhalation albuterol

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12
Q

What is the exacerbation dosing for children 0-4 years old for Combivent Respimat?

A

4-8 inhalations every 20 minutes PRN for up to 3 hours with VHC and mask

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13
Q

What is the exacerbation dosing for children 5-11 years old for Combivent Respimat?

A

4-8 inhalations every 20 minutes PRN for up to 3 hours with VHC

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14
Q

What is the standard adult dosing for Combivent Respimat?

A

1 inhalation every 6 hours

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15
Q

What is the exacerbation dosing for adults for Combivent Respimat?

A

8 inhalations every 20 minutes PRN for up to 3 hours

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16
Q

What are the adverse effects associated with Combivent Respimat?

A
  • Ipratropium: dry mouth, urinary retention, infection, sinusitis, bronchitis
  • Albuterol: tachycardia, tremor, hypokalemia, irritability
17
Q

What is the brand name for ipratropium/albuterol nebulizer solution?

A

DuoNeb

18
Q

What dosage form is DuoNeb available in?

A

Nebulizer solution

19
Q

What is the standard dosing for children 0-4 years old for DuoNeb?

A

1.5 ml every 20 minutes for 3 doses, then PRN

20
Q

What dose is DuoNeb available in?

A

0.5 mg/2.5 mg per 3 ml vial

21
Q

What is the standard dosing for children 5-11 years old for DuoNeb?

A

3 ml every 20 minutes for 3 doses, then PRN

22
Q

What is the standard adult dosing for DuoNeb?

A

3 ml every 20 minutes for 3 doses, then PRN (off-label)

23
Q

Give one clinical pearl for DuoNeb.

A

May be used for up to 3 hours in initial management of severe exacerbations.

Spring 2020: P1 Therapeutics (12 decks)

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