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Spring 2020: P1 Therapeutics > Maintenance Inhalers: Long Acting Beta Agonists > Flashcards

Maintenance Inhalers: Long Acting Beta Agonists Flashcards

1
Q

How do long acting beta agonists work?

A

They increase cAMP, which relaxes bronchial smooth muscle relaxation and inhibits hypersensitivity mediators from mast cells (histamine and leukotrienes).

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2
Q

What is the brand name of arformoterol tartrate?

A

Brovana

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3
Q

What form is arformoterol tartrate available in?

A

Nebulizer solution

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4
Q

What age groups can Brovana be used for?

A

Adults (COPD) only

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5
Q

What is the brand name of formoterol?

A

Perforomist

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6
Q

What form is Perforomist available in?

A

Nebulizer solution

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7
Q

What age groups can formoterol be used in?

A

Adults (COPD) only

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8
Q

What is the brand name of indacaterol?

A

Arcapta Neohaler

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9
Q

What inhaler form is indacaterol available in?

A

Neohaler

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10
Q

What age groups can Arcapta Neohaler be used in?

A

Adults (COPD) only

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11
Q

What is the brand name of olodaterol?

A

Striverdi Respimat

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12
Q

What inhaler form is olodaterol available in?

A

Respimat

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13
Q

What age groups can olodaterol be used for?

A

Adults (COPD) only

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14
Q

What is the brand name for salmeterol?

A

Serevent

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15
Q

What inhaler form is Serevent available in?

A

Diskus

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16
Q

What age groups can salmeterol be used for?

A

Children 5-11 years old and adults

17
Q

What are the adverse effects associated with LABAs?

A
  • Tachycardia
  • Headache
  • Tremor
  • Hypokalemia
18
Q

What are the two boxed warnings for LABAs?

A
  1. Increased risk of asthma-related death for all monotherapy LABA use; should not be used alone for asthma management
  2. Increases hospitalizations in pediatric and adolescent patients
19
Q

Prolonged ____ seen with intentional overdoses.

A

QT

20
Q

Can LABAs be used for acute symptoms?

A

No

21
Q

Give two clinical pearls for LABAs.

A
  1. May be helpful for exercise-induced bronchospasms
  2. Formoterol and indacaterol capsules should NOT be taken orally
22
Q

What pediatric consideration is needed with LABAs?

A

Most children under 4 cannot provide sufficient inspiratory flow for adequate lung delivery with a DPI

Spring 2020: P1 Therapeutics (12 decks)

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