Maintenance Inhalers: Long Acting Beta Agonists Flashcards
How do long acting beta agonists work?
They increase cAMP, which relaxes bronchial smooth muscle relaxation and inhibits hypersensitivity mediators from mast cells (histamine and leukotrienes).
What is the brand name of arformoterol tartrate?
Brovana
What form is arformoterol tartrate available in?
Nebulizer solution
What age groups can Brovana be used for?
Adults (COPD) only
What is the brand name of formoterol?
Perforomist
What form is Perforomist available in?
Nebulizer solution
What age groups can formoterol be used in?
Adults (COPD) only
What is the brand name of indacaterol?
Arcapta Neohaler
What inhaler form is indacaterol available in?
Neohaler
What age groups can Arcapta Neohaler be used in?
Adults (COPD) only
What is the brand name of olodaterol?
Striverdi Respimat
What inhaler form is olodaterol available in?
Respimat
What age groups can olodaterol be used for?
Adults (COPD) only
What is the brand name for salmeterol?
Serevent
What inhaler form is Serevent available in?
Diskus
What age groups can salmeterol be used for?
Children 5-11 years old and adults
What are the adverse effects associated with LABAs?
- Tachycardia
- Headache
- Tremor
- Hypokalemia
What are the two boxed warnings for LABAs?
- Increased risk of asthma-related death for all monotherapy LABA use; should not be used alone for asthma management
- Increases hospitalizations in pediatric and adolescent patients
Prolonged ____ seen with intentional overdoses.
QT
Can LABAs be used for acute symptoms?
No
Give two clinical pearls for LABAs.
- May be helpful for exercise-induced bronchospasms
- Formoterol and indacaterol capsules should NOT be taken orally
What pediatric consideration is needed with LABAs?
Most children under 4 cannot provide sufficient inspiratory flow for adequate lung delivery with a DPI
