Required Readings - Final Flashcards
What contributes to systemic glucotoxicity?
Increased hepatic glucose output, which leads to further complications of chronic disease
What contributes to fatty liver disease?
Increased glucose and fatty acid uptake (increased conversion to TGs and VLDLs)
What does increased pancreatic islet mass followed by exhaustion lead to?
Pre-diabetes, followed by overt diabetes
In metabolic syndrome, what are some examples abnormal GI activity?
- Increased dietary fat and sugar absorption
- Increased gut motility
What contributes to increase fat storage and fat tissue hypertrophy in visceral adipose tissues?
- Decreased glucose uptake
- Increased lipid uptake
- Increased lipolysis
What does increased fat storage and fat tissue hypertrophy in adipose tissue lead to?
Systemic low-grade inflammation
What leads to systemic lipotoxicity, and will lead to complications of chronic diabetes?
Increased lipolysis in visceral adipose tissues
How is satiety altered in metabolic syndrome?
-Abnormal hedonic and homeostatic response
What contributes to abnormal satiety?
CCk, Ghrelin, PPY, increase in ECs
What contributes to abnormal nutrient sensing?
- Increased insulin
- Increased dietary nutrients, CCK
(T/F) Both insulin and glucagon increase in MetS
T
Insulin (resistance)
Glucagon increases because cells “starved”
What does incretin control?
GLP-1 and GIP
What are the actions of incretin? (4)
- Stimulate insulin release-Inhibits glucagon release
- Increases insulin sensitivity
- Effects on gut-motility
In MetS, incretin increases/decreases?
Decreases
Which gut hormone increases?
EC
Which gut hormone decreases?
GLP-1 (under the influence of incretin)
Which adipose tissue hormone increases?
Leptin, but with resistance
Adiponectin
What are the effects of increased leptin resistance?
-Decreased satiety and decreased energy expenditure.
What are the effects of decreased adiponectin?
- Increased gluconeogenesis
- Decreased glucose uptake
- Decreased insulin sensitivity
- Increased body-weight
- Decreased endothelial function
What are the abnormal muscle functions in MetS?
Decreased glucose uptake while fatty-acid uptake increases
Risk factors that should be assessed for T2DM annually?(CP-FHH)
- CVD risk factor
- Presence of end-organ damage associated with diabetes
- Family history
- History of GDM/pre-diabetes
- High risk populations
No risk factors present in <40 y/o pt or low-moderate risk?
No screening, continue to assess risk factors
No risk factors, but >40 y/o or high risk?
Screen every 3 years
Presence of risk factors OR very high risk?
Screen every 6-12 months?
High risk?
33% of developing T2DM within 10 years
Very high risk?
50% of developing T2DM within 10 years
How to screen?
FPG or AIC
FBG 6.1-6.9?
IFG
FBP >/= 7.0?
Diabetes
A1C 6.0-6.4 %
Prediabetes
A1C >/= 6.5%?
Diabetes
Meds for patient with CVD and diabetes?
Statin + ACEi/ARB + ASA
Patient with CVD and diabetes started on meds, but NOT at glycemic targets?
Add Liraglutide, Emaglifloinor Canafliglozin (ONLY for T2DM)
Patient has NO CVD, but has microvascular disease. What meds?
Statin + ACEi/ARB
Patient has NO CVD or microvascular disease BUT >55 with additional CV risk factors. What meds?
Statin + ACEi/ARV
When is ONLY a statin prescribed in T2DM for cardiovascular protection?
- Age >/= 40
- Age>/= 30 and diabetes >15 years
- Warranted for statin therapy based on Canadian CVD Lipid guidelines
____ should be used as a secondary prevention in cardiovascular disease prevention in diabetics.
ASA
How can we keep patients safe when they are at risk of HypoG? (RAPR)
- Recognize
- Act/Treat
- Prevent
- Reduce Driving Risk
How can we reduce driving risk?
Educate patients to drive safely with diabetes by:
- Prepare w/ fast acting sugar nearby
- Be ware of BG every 4 hours during long drives
- Stop driving and treat symptoms
- After treating, wait until BG > 5 mmol/L to start driving again
Brain function may not be fully restored until ___ after hypoG is resolved
40 mins
How can we keep patients safe when they are at risk of dehydration (V/D)?
- Rehydrate appropriately, avoid caffeine (Water, broth, diet drinks, sugar free beverages Ok)
- Hold SADMANS and restart when able to drink/eat normally
What are SADMANS meds that should be stopped then resumed when pt can eat/drink normally?
- Sulfonylureas/Secretagogues
- ACEi
- Diuretics
- Metformin
- ARB
- NSAIDs
- SGLT2 inhibitors
Discuss consideration for women with T1DM and T2DM who wish to conceive
- A1C <7% –> Aim for <6.5%
- Stop certain meds
- Start folic acid supplementation
- Screen for complications
- Aim for healthy BMI
- Ensure vaccinations have occured
- Refer to diabetes clinic
Which meds should be stopped prior to conception?
- Non-insulin antiHG meds EXCEPT for metformin/glyburide
- Sating
- ACEi/ARB
What may be used until the detection of pregnancy if nephropathy exists?
ACEi or ARB
What meds may need to be begun prior to conception?
- Insulin if target A1C not achieved on metformin/glyburide
- Other antiHTN agents safe for pregnancy if HTN control needed
3 quick questions to help patients to meet their goals?
1) Ask them to rate the IMPORTANCE of their goals (high, medium low)
2) Ask them to rate the CONFIDENCE of achieving their goals
3) Ask to set a SMART goal before next meeting
What are some suggestions of goals?
-Eat healthy
-Check feet
-Manage stress
-Be more active
(Practical/simple recommendations)
Goal of CANRISK?
To determine risk of having pre-diabetes or T2DM (NOT Type 1)
CANRISK age?
For adults aged 40-74 years
Key CANRISK questions? (WAGE-H-BPFDE)
Waist C Age Gender Ethnicity HTN BMI PA Family history Diet (Fruits & Veg) Education
CANRISK<21?
Low risk
CANRISK 21-32?
Mod risk
CANRISK >33 ?
High risk
How does MetS contribute a financial and social burden?
MetS is a leading cause of blindness, amputation and kidney failure
Main underlying cause of MetS?
Insulin resistance an central obesity
How does the IDF based the definition of MetS?
The need for early diagnosis and treatment
Official IDF definition of MetS?
Central obesity (WC) plus and two out of four factors
What are the 2/4 factors that must be present for Mets?
-Raised TGs
-Reduced HDL
-High BP
-High FBG
OR treatment of any of these abnormalities (i.e. even if they are on medications and normal levels, still considered MetS)
Important to consider about central obesity?
WC must be ethnicity specific
HIGHEST WC for MetS?
USA (102 cm Men and 88 Women)
LOWEST WC for Met S?
South asians, chinese and japanese (90 cm Men and 80 cm women)
Examples of additional metabolic measurements for research in MetS?
- abnormal BF distribution
- Pro-inflammatory state
- Prothrombotic state
- Hormonal factors
Primary intervention of MetS from IDF?
- Moderate kcal restriction to achieve 5-10% weight-loss in 1st year
- Moderate increase in PA
- Changes in dietary consumption
Secondary intervention of MetS from IDF?
Drug therapy (when lifestyle not enough and who are at high risk for CVD)
What is the pathogenesis of MetS?
Primary underlying cause is insulin resistance and central obesity
Is MetS a valid indicator of CVD?
Not an absolute risk factor, but those with MetS increase risk of major CVD events x2.
People with diabetes and Mets S have a much _____ than those with T2DM alone
Higher CVD risk
Is the risk of CVD greater in MetS than the sum of its parts?
Studies are contradictory
How were the WC for men and women in the US determined?
ATP III (Adult Treatment Panel)
(T/F) As a general rule, alcohol should be avoided in diabetes
False
What is important prior to drinking alcohol?
That patients diabetes in under control, knowledgeable of preventing low blood sugar ad free from health problems that could where alcohol may aggravate diseases.
Mod alcohol women?
<2 SD/day and <10/week
Mod alcohol men?
<3 SD/day and <15/week
SD beer?
341ml/12 oz
SD spirits?
43ml/1.5oz
SD wine?
142 ml/5 oz
(T/F) in CHO counting,CHO’s MUST be counted for within the alcoholic drinks, and insulin should be adjusted
False
What may delay hypoG?
When alcohol is consumed with, or 2-3 hours after an evening meal
In delayed hypoG, when does it arise?
Next morning, or 24 hours after consumptions
(T/F) Only T1DM must be cautious of alcohol, as they must CHO count
False, T2DM who are using insulin or insulin secretagogues
Risks of alcohol?
- Increase Bp and TGs
- Damage to liver/nerves
- Inflammation of pancreas
- Dehydrate body –> very dangerous if high blood sugar
Recommendations before drinking alcohol?
1) Always have treatment for low BG with you
2) Have someone know your signs and symptoms of hyperG
3) Wear diabetes ID
What is the danger of glucagon when alcohol is in the body?
Glucagon will NOT work. Ambulances should be called if a diabetic passes out.