Reproductive System = male Flashcards

1
Q

testes are located in ___ which are ___

A

in scrotum
sac of skin + superficial fascia outside the abdominopelvic cavity at root of pains
more pigmented + more hairs

midline septum = gives each testes its own compartment

exterior posiition = colder than core temp
imp = for spermatogenesis to occur normally

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2
Q

tunics

A

tunica vaginalis
outer 2 layered

tunica albuiginea.= fibrous capsule of testes
septal extensions divide tested into hundreds of lobules

each lobule = 1-4 seminiferous tubules

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3
Q

roles of dartos and cremaster muscles In testicular temp reg

A

dartos = controls how close testes are to make body
if cold: contract up close to body
hot: relax far from body

and wrinkles skin to reduce SA for heat loss

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4
Q

pathway sperm takes to get to ductus vas defers

A

seminferous tubules

tubules rectus

rete testes
efferent ductules

epididymis

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5
Q

Leydig cells

A

interstitial cells that produce androgens (testosterone)

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6
Q

blood supply

A

testicular arteries (from abdo aorta)
testicular veins form pampiniform plexus = helps w temp reg, cooling of blood from body temp

spermatic cord = enclosed tube having vas deferens, blood + lymphatic vessels, nerves going back to abdo.

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7
Q

epididymis

A

head = superior pat of testis
receives sperm from efferent ductules
merges to body and tails have highly copied ducts
sperm that enter here = immature and nonmotile

takes 20 days to traverse epididymis = gain ability to swim

+ develop receptors for egg mb
so if get close enough to an egg = is now able to bind to it.

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8
Q

what happens to the empidiymis during ejaculation

what happens to sperm that do not get ejaculated for a long period of time

how long can sperm be stored in the epididymis

A

contractile activity of smooth muscles pushes forward
if sperm is stored in tail, will be moved out of the males body.

degenerated and parts are recycled

stored in tail, after maturation for 20 days, for 2-3 months
will grow old and be degenerated.
undergo phagocytosis and recycled.

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9
Q

ducts vas deferens

A

1 per testes
pathway taken by the vas deferns to the ejaculatory duct

vas deferens goes up on top of the bladder and around, the thicker part = ampula
merges into the ejaculatory duct (when joins w duct of seminal vesicles

passes into the prostate gland as it merges into the urethra

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10
Q

vasectomy
what is
risks

A

cutting and tying the vas deferens
reversible, most of the time

not much risk,
reversiblity is not guaranteed
is a day procedure, no biggy

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11
Q

urethra

A

terminal portion
urinary and reproductive functions

3 regions
prostatic
intermede
spongy urethra

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12
Q

reproductive accessory glands

A

produce secretions that make up semen (with sperm)

ex.
seminal vesicles
prostate glands
bulbourethral glands

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13
Q

seminal vesicles (2)

A

posterior walls of bladder
contribute most of semen value
bumpy yellow structure

sperm (from vas deference) and seminal fluid (from here) go to ejaculaotry duct

semen = yellow, viscous, alkaline (bc vagina is acid)
fructose and citric acid (E source for sperm)
coagulating enzymes = make a clot = helps semen stay in reproductive tract of women.

prostaglandins + other substances to promote sperm motility/fertalizing ability)

yellow bc of flavin proteins = fluoresce under UV light.

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14
Q

prostate gland

A

simple gland
encircles urethra
inf to bladder

milky secretions, about 1/3 of semen volume

have enzymes = activating sperm

secretions to prostatic urethra via several ducts during ejaculation

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15
Q

bulbourethral glands (2)

A

pea sized
inf to prostate
make a thick clear mucus to spongy urehtra before ejaculation

go through spongy urethrea to get rid of remnants of ruine and as a lubricant during sex.

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16
Q

penis as a copulatry organ

external and internal parts

A

deliver sperm to female reproductive tract

external genetilia = penis + scrotim
penis = att root + free shaft of body
tip/head = glans penis
foreskin/prepuce = skin that is cut off around the glands in a circumcision

internal
spongy urethra
3 corpora of erectile tissue
= 2 corpora cavernosa = 2 side ones
= 1 midventra corpus spongiosom

cavernosa = resp ofr erection
deep arteries resp for blood supply during erection

17
Q

semen composition

A

provide =
transport medium
nutrients (fructose + citric acid) = to survive
chemicals (PGs, ATP, antibiotic chemicals) = energy source + protects sperm

protect/activate sperm or support sperm transport.

ph = 7.2/7.6 to neutralize the pH of the vagina of 3.5-4

18
Q

regulation fo make reproductive function

A

200 M per day
testis is source of both germ cells and hormones.
testis =
seminferous tubule = Steroli cells + spermatogenesis intermediates
leydig cells = synth andorgens (testosterone)
in bn tubules

19
Q

actions of testosterone

A

growth maturation of gonads/accessory organs = puberty

essential for spermatogenenis

adolescent growth spurts (start/stop)
growth of layrynx and vocal cords
secretion of sweat
hair (face, chest, armpit, groin)

maintenance of libido
aggressions

inc EPO from kidneys = site RBC prod = higher hematocut

first event = inc size and activity of testes = provides T for rest of events to occur

20
Q

hypothalamic and pituitary regulation of steroidogenis in the male

A

anterior pituitary hormone
gonadotropins = glycoproteins = water soluble = w cell surface receptors
begin to target cells to activate process that reg enzymes or open up channels
faster response than transcription factors

FSH = follicle stimulating hormone
stimulate sterile cells to support spermatogenesis = T required

LH = luteinizing hormone = stimulate leydig cells to secrete T

21
Q

hypothalamic-pituitary-testicular axis

A

hypothalamus releases Gonadoptropin releasing hormone = GnRH

GnRH stems the ant. pit. to release LH

LH stim leydig cells to prod. T

neg. feedback reg secretion/production of T

as levels rise, inh hypo and pit. so levels go down, so feedback goes away, so levels go up
constant fluctuation
for a relatively steady state of prod.

22
Q

lipid soluble hormone pathway

A

If T is acting on target cells, doesn’t have to bind to receptr, gets in easy
Finding receptor assoc w nucleus/dna,
Inc transcription of specific genes reg by testosterone.
Makes mRNA, makes protein that carries out effect

23
Q

water soluble hormone

A

LH binds to cell surface receptor to inc prod of T
receptor assoc w G protein

active receptor activates G protein

G protein activates adenylyl cyclase which converts ATP to cAMP

activates protein kinase A

phos proteins that inc the transport of cholesterol into mitochondria
+ another protein that turns into test.

24
Q

GnRH

A

gonadotropin releasing Hormone
pusatile secretions by hypothalamic neurons
stim secretions of FSH nad LH

25
inhibin
released by steroli cells inh secretions of only FSH so only LH is released. imp for female system (sometimes want one but not both)
26
main steps in spermatogenesis
starting point = spermatogonium = diploif self-perpetuating keeps itself going so there is always stem cells to daily produce an insane number of mitotic divison= - stem cell divides, one cell goes through development, other stays to maintain stem cell pop primary sperm = duplicates and divides into 2 cells = secondary divides again to 2 spermatids. total = 4 completed meiosis but don't look like sperm undergo morphological changes to become long and skinny from 1o sperm to fully matured sperm needs 70 days
27
spermatogonium
2N type A daughter stays behind to maintain stem cell pop type B becomes 1o spermatocyte and enters into meiosis
28
1o spermatocyte
2N starting point of meitotic division 1st round = two 2o spermatocyte
29
2o spermatocyte
1N 2 copes of each of 23 chromosome but joined togethers 2nd division = 2 haploid spermatides
30
spermatids
N round cell 22 chromes + X/Y chromosomes.
31
spermatozoan
from spermatids (round) to this (sperm) needs structural reorganization. nucleus gonna get pushed up cytoplasm = discarded mitochondria = line up In mid piece region flagella grows cap = acrisome = essnetial for fertilizing egg. acquire ability to swim and Fert egg.
32
where are spermatids and spermatocytes found
spermatids and spermatocytes at various stages are embedded in steroli cells steroli cells sit on basement mb tight jns create 2 compartments basal compartment adlunmial compartmetns (towards lumen)
33
steroli cells roles
nourish developing sperm cells = use cells secrete fluid into lumen of seminfurous tubule (that carry sperm along pathway digest cytoplasm discarded by sperm cells bind FSH and test (stim steroli cells ot do things ot maintain spermatogenesis to keep happening. produce inhibit = inh release of FSH
34
blood testis barrier
created by tight junctions so all stages after initiation of meiosis is done in avascular and separate env sep from immune cells passing in circ are fragile and haploid so are vulnerable
35
role of Leydig cells
in bn each tubule = allows them to have good blood supply - vascularized imp to bring hormones (like LH to make T from cholesterol) and cholesterol itself has enzymes to cat. steps in T synthesis has cell surface receptors for LH = stim to secrete T to = support spermatogenesis = support accessory organs