Reproductive Physiology Flashcards
oogenesis
the production, growth, and maturation of an egg, or ovum
how does oogenesis begin?
in the fetal ovaries, stem cells called oogonia produce primary oocytes
primary oocytes
diploid cells resulting from mitosis & differentiation of oogonia during fetal development
what phase of meiosis are primary oocytes in?
prophase of meiosis I; they are unchanged from the way they were produced in the fetus
- a number of primary oocytes restart meiosis early in the menstrual cycle and become secondary oocytes
secondary oocytes
after completing meiosis I, these are produced along with a polar body and one will be released into the fallopian tube
when does meiosis II end?
at exactly the time the sperm contacts the egg for fertilization
ovarian cycle
cyclic changes that occur in the ovaries for the development of eggs
what are the phases of the ovarian cycle?
follicular and luteal phase
follicular phase
where the egg and surrounding cells (follicle) develop up to the point of ovulation
luteal phas
where leftover bits of follicle remain and secrete hormones (progesterone) to prepare the lining of the uterus (endometrium) for a fertilized egg
granulosa cells
the majority of the cells surrounding an oocyte in a follicle; develop alongside oocyte and become more cuboidal, will start secreting estrogen, will develop secondary follicle around the follicle + has fluid-filled chambers (antrum)
when is oocyte development stalled?
halfway through meiosis II
corpus luteum
leftover support cells secreting copious amounts of estrogen and progesterone, yellow due to cholesterol
corona radiata
the layer of granulosa cells that surround an oocyte after is has been ovulated
how does a primordial follicle become a primary follicle?
under the influence of LH and FSH, formation of cuboidal granulosa cells from flat cells and zona pellucida
zona pellucida
proteinaceous cells that forms around the ovum, barrier sperm need to make through
how do primary follicles transition to secondary follicles?
when granulosa cells secrete follicular fluid and form an antrum
how do secondary follicles transition to mature follicles?
when the antrum becomes one continuous fluid-filled space allowing for separation from oocyte from support cells
homeostasis in the ovary
- negative feedback
1. low blood estrogen lvls feed back to hypothal. to release GnRH, which talks to ant. pit. to tell it to release LH and FSH
2. LH stimulates estrogen production which inhibits release of GnRH
3. granulosa cells can make copious amounts of estrogen which can stim. GnRH (+ve feedback in midst of -ve feedback)
4. LH surges causing follicle rupture and egg release
luteinizing hormone (LH)
secreted by the pituitary gland to promote production of hormones from the gonad
follicle stimulating hormone (FSH)
secreted by the pituitary gland to stimulate maturation of gametes
stratum basalis of endometrium
permanent layer - builds the functional layer after each menstruation