Reproductive Hormones Flashcards
GnRH meaning
Gonadotropin Releasing Hormone
Source of GnRH
Hypothalamic surge and tonic centers
Female and Male Primary Action of GnRH
Release of FSH and LH from anterior lobe-pituitary
Source of LH
Anterior lobe (pituitary) gonadotroph cells
Male Primary Action of LH
Stimulates testosterone production
Female Primary Action of LH
Stimulates ovulation, formation of CL and progesterone secretion
Source of FSH
Anterior lobe (pituitary) gonadotroph cells
Male Primary Action of FSH
Sertoli cell function
Female Primary Action of FSH
Follicular development and estradiol synthesis
Source of Prolactin
Anterior lobe (pituitary) lactotroph cells
Male Primary Action of Prolactin
Can induce maternal behavior
Female Primary Action of Prolactin
Lactation, maternal behavior and corpora lutea function
Sourced of Oxytocin (OT)
Synthesized in the hypothalamus, stored in the posterior-lobe pituitary, synthesized by corpus luteum
Male Primary Action of Oxytocin
PGF2a synthesis and pre-ejaculatory movement of spermatozoa
Female Primary Action of Oxytocin
Uterine motility, promotes uterine PGF2a synthesis, milk ejection
Source of Estradiol (E2)
Granulosal cells of follicle, placenta, Sertoli cells of testis
Male Primary Action of E2
Sexual behavior
Female Primary Action of E2
Sexual behavior, GnRH, elevated secretory activity of entire tract, enhanced uterine motility
Source of Progesterone
Corpus luteum and placenta
Female Primary Action of P4
Endometrial secretion, inhibits GNRH release, inhibits reproductive behavior, promotes maintenance of pregnancy
Source of Testosterone
Interstitial cells of Leydig, cells of theca interna in female
Male Primary Action of Testosterone
Anabolic growth, promotes spermatogenesis, promotes secretion of accessory sex glands
Female Primary Action of Testosterone
Substrate for E2 synthesis, abnormal masculinization (hair patterns, voice, behavior, etc)
Source of Inhibin
Granulosa cells (female)
Sertoli cells (male)
Male and Female Primary Action of Inhibin
Inhibits FSH secretion
Source of Activin
Granulosal cells (female)
Sertoli cells (male)
Placental cells (female humans)
Male and Female Primary Action of Activin
Stimulates FSH secretion
Source of Prostaglandin F2a
Uterine endometrium, vesicular glands
Male Primary Action of PGF2a
Affects metabolic activity of spermatozoa, causes epididymal contractions
Female Primary Action of PGF2a
Luteolysis, promotes uterine tone and contraction, ovulation
Source of Prostaglandin E2
Ovary, Uterus, Embryonic membranes
Female Primary Action of PGE2
Ovulation, stimulates corpus luteum secretion of progesterone
Source of human chorionic gonadotropin (hcG)
Trophoblast of blastocyst (chorion)
Male Primary Action of hCG
Increase growth of fetal testis
Female Primary Action of hCG
Facilitate production of progesterone by ovary
Source of Equine chorionic gonadotropin (eCG)
Chorionic girdle cells
Female Primary Action of of eCG
Causes formation of accessory corpora lutea
Source of placental lactogen
Placenta
Female Primary Action of Placental lactogen
Mammary stimulation of dam
It is from CL, uterus, and placenta; at the end of pregnancy it stimulate opening of cervix, relaxation of pelvic ligaments, and separation of pelvic symphysis (parturition)
Relaxin
It is less abundant and less effective than testosterone, made by Leydig cells
Androstenone
(I) Follicular Phase, what is the pituitary hormone effect?
LH and FSH stimulate several follicles to grow
(II) Ovulation, what is the pituitary hormone effect?
LH and FSH stimulate maturation of one of the growing follicles
(III) Luteal Phase, what is the pituitary hormone effect?
LH stimulates growth of a CL from follicular tissue left behind after ovulation
In males, what is the pituitary hormone effect?
LH and FSH stimulate spermatogenesis and testosterone secretion by the testes
In males, what is the testosterone hormone effect?
Testosterone and inhibin inhibit the secretion of GnRH by the hypothalamus and LH and FSH by the pituitary
HPG means?
Hypothalamus-Pituitary-Gonadal Axis
FSH and LH levels are elevated
At birth
E2 and T4 activate HPG axis that will result to physiological changes
At puberty