Reproduction Flashcards
diploid cells (2n)
contain two copies of each chromosome
haploid (1n)
contain only one copy of each chromosome
cell cycle
eukaryotic cell replication; G1, S, G2, M phases
interphase
G1, S, G2; longest part of the cell cycle
G0 stage
cell is simply living and serving its function, without any preparation for division
chromatin
less condensed form of chromosomes
G1 stage
cells create organelle for energy and protein production while also increasing their size
restriction point
governs pass from G1 into S phase; certain criteria must be met
S stage
cell replicates its genetic material so that each daughter cell will have identical copies
sister chromatids
identical chromatids bound to each other after replication
centromere
specialized region that holds sister chromatids together
G2 stage
cell passes through another quality control checkpoint; cell checks to ensure that there are enough organelles and cytoplasm to divide between two daughter cells; also checks to make sure that DNA replication proceeded correctly
M stage
consists of mitosis as well as cytokinesis
p53
main protein in control of repairing DNA at the restriction point
cyclin dependent kinases (CDK)
responsible for the control of the cell cycle; presence of the right cyclins are required to activate them
transcription factors
promote transcription of genes required for the next stage of the cell cycle
cancer
result of damaged cells being allowed to undergo mitosis
TP53
gene that makes p53; when this is mutated, cell cycle is not stopped to repair DNA; allows mutations to accumulate, eventually resulting in a cancerous cell that divides uncontrollable
tumor
result of cancerous cell undergoing rapid cell division
metastasis
spread of cancerous cells through the blood stream or lymph systems
mitosis
process by which two identical daughter cells are created from a single cell
somatic cells
cells not involved in sexual reproduction
Prophase
- condensation of the chromatin into chromosomes
- centriole pairs separate, move toward opposite sides of cell
- spindle fibers begin to form
- nuclear membrane dissolves
- kinetechores appear at the centromere
centrosome
region that contains paired cylindrical organelles called centrioles; responsible for correct division of DNA
spindle fibers
made up of microtubules
asters
anchor centrioles to cell membrane
kinetochores
protein structures located on the centromeres that serve as attachment points for kinetochore fibers
Metaphase
kinetochore fibers interact with the fibers of the spindle apparatus to align the chromosomes at the metaphase plate
Anaphase
- centromeres split so that each chromatid has its own distinct centromere
- sister chromatids separate, pulled toward opposite poles of the cell by shortening of kinetochore fibers
telophase
- spindle apparatus disappears
- nuclear membrane reforms around each set of chromosomes, nucleoli reappear
- chromosomes uncoil, resuming chromatin form
- Each nucleic has received a complete copy of the genome identical to the original genome
cytokinesis
separation of the cytoplasm and organelles so that each daughter cell has sufficient supplies to survive
gametocytes (germ cells)
cells related to sexual reproduction
gametes (sex cells)
sperm and eggs, in humans
Meiosis I
homologous chromosomes are separated, generating haploid daughter cells; reductional division
Meiosis II
separation of sister chromatids; equational division
homologous pairs
a pair of chromosomes, each of which contains one chromosome inherited from each parent
Prophase I
- chromatin condenses into chromosomes
- spindle apparatus appears
- nucleoli and nuclear membrane disappear
- crossing over
synapsis
process of homologous chromosomes coming together and intertwining
tetrad
the result of synapsis; four sister chromatids
synaptonemal complex
group of proteins holding homologous chromosomes together
chiasma
point of contact between homologous chromosomes
crossing over
when chromatids of homologous chromosomes break at the chiasma, exchanging equivalent pieces of DNA
genetic recombination
happens during crossing over; increasing the variety of genetic combinations that can be produced during gametogenesis
Mendel’s second law of independent assortment
explained by crossing over; states that the inheritance f one allele has no effect on the likelihood of inheriting certain alleles for other genes
metaphase I
homologous pairs align at he metaphase plate, each pair attaches to a separate spindle fiber by its kinetochore
anaphase I
homologous pairs separate and are pulled to opposite poles of the cell; called segregation