Repro 5 Flashcards

1
Q

when is routine cervical screening offered in Scotland

A

every 3 years 25-49

every 5 years 50-64

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2
Q

if smear shows signs of inflammation, what is the next steps?

A

repeat in 6 months

- colposcopy if 3 abnormal smears

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3
Q

if smear is borderline/mild dyskariosis, what are the next steps?

A

if -ve for HPV – back to routine screning

if +ve referral for colposcopy

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4
Q

if smear shows severe dyskariosis/suspected invasion, what are the next steps?

A

urgent colposcopy referral (within 2 weeks)

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5
Q

stains used in colposcopy

A

acetic acid

lugol’s iodine

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6
Q

what is the most common cause of post menopausal bleeding

A

atrophic vaginitis

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7
Q

pathophysiology of atrophic vaginitis

A

lack of oestrogen support for the vaginal epithelium

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8
Q

symptoms of atrophic vaginitis

A

post-menopausal woman

  • vaginal dryness
  • pain during sex
  • spotting after sex
  • frequent UTI
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9
Q

symptoms of pelvic inflammatory disease

A
constant lower abdomen pain 
purulent discharge 
pain during sex
irregular bleeding 
adnexal tenderness
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10
Q

most common cause of pelvic inflammatory disease

A

ascending infection from endocervix

  • chlamydia
  • gonorrhoea
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11
Q

treatment of mild pelvic inflammatory disease

A

oral ofloxacin + metronidazole 14 days

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12
Q

treatment of moderate pelvic inflammatory disease

A

IM ceftriazone + oral dozycycline + oral metronidazole 14 days

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13
Q

what is endometriosis

A

presence of endometrial tissue outside of the uterus

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14
Q

symptoms of endometriosis

A

painful periods
pain during sex
chronic pelvic pain

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15
Q

endometriosis on USS

A

chocolate cysts

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16
Q

diagnostic for endometriosis

A

laparoscopy

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17
Q

tx endometriosis

A
NSAIDS
combined oral contraceptive
mirena coil 
danazol - synthetic steroid 
surgical - laparoscopic ablation/ hysterectomy
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18
Q

tender vulval abscess, unilateral vulval swelling, dyspareunia
most likely?

A

bartholin abscess

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19
Q

medical management of menorrhagia

A

tranexamic acid
mirena coil
combined pill
GnRH analogues

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20
Q

what drugs can shrink fibroids

A

GnRh agonists - lupron

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21
Q

what is premenstrual syndrome

A

distressing physical, behavioural + psychological symptoms occurring in the LUTEAL phase of menstruation

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22
Q

symptoms of premenstrual syndrome

A
depression 
anxiety 
irritability 
bloating
mastalgia 
increased appetite
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23
Q

blood results menopause

A

High FSH + LH

low oestrogen

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24
Q

menopause symptoms

A
hot flushes
night sweats
vaginal dryness
pain during sex 
mood change
loss of libido
25
Q

what hormone is dominant in the proliferative phase of the uterine cycle

A

oestrogen

26
Q

what hormone is dominant in the luteal phase of the uterine cycle

A

progesterone

27
Q

how is ovarian reserve tested

A

AMH or antral follicle count

28
Q

AMH in PCOS

A

High AMH- lots of small follicles

29
Q

which primitive duct becomes male genitals

A

Wolffian duct

30
Q

which primitive duct becomes female genitals

A

mullerian duct

31
Q

which cells produce testosterone

A

leydig cells

32
Q

site of spermatogenesis

A

sertoili cells in seminiferous tubules

33
Q

what stimulates spermatogenesis

A

FSH + Testosterone

34
Q

what stimulates release of testosterone

A

LH

35
Q

what cells in the anterior pituitary secrete LH

A

theca cells

36
Q

what cells in the anterior pituitary secrete FSH

A

granulosa cells

37
Q

route of sperm

A

testes - epididymis - vas deferens - ejaculatory duct - urethra

38
Q

erection is under what control

ejaculation is under what control

A

parasympathetic

sympathetic – smooth muscle contraction

39
Q

normal testes volume

A

12-25 mls

40
Q

first line urge incontinence

A

bladder retraining

41
Q

first line stress incontinence

A

pelvic floor exercises

42
Q

tx of endometrial cancer confined to the uterus

A

total abdominal hysterectomy + bilateral salping-oophorectomy

43
Q

tx of endometrial cancer that has spread

A

surgery (total hysterectomy + salpingo-oophorectomy) + radiotherapy

44
Q

when should progesterone levels be tested in a woman

A

7 days before end of cycle

45
Q

most common type of epithelial ovarian cancer

A

serous

46
Q

what ovarian tumour causes endometrial hyperplasia

A

granulosa cell carcinoma

- can present as DUB due to hyperplasia

47
Q

what age group gets ovarian germ cell tumours

A

women in 20s

48
Q

what ovarian cancer causes hypercalcaemia

A

small cell carcinoma of the ovary

49
Q

what ovarian tumour is associated with endometriosis

A

clear cell carcinoma

50
Q

what is commonly mutated in serous endometrial cancer

A

TP53

51
Q

what is the driver behind endometriod cancer

A

unopposed oestrogen

52
Q

who gets oestrogen + progesterone HRT

A

women who still have a uterus

- decreases risk of endometrial cancer

53
Q

average age of menopause
early menopause
premature menopause
late menopause

A

51
<45
<40
>54

54
Q

breast screening programme

A

3 yearly for women 50-70

55
Q

drug given to HER2 +ve breast cancer

A

herceptin

56
Q

drug given to ER +ve breast cancer in

  • premenopausal women
  • post menopausal women
A

tamoxifen (increased risk of endometrial cancer)

letrozole (increased risk of oesteoporosis)

57
Q

when does fetal anomaly scan take place

A

18- 20+6 weeks

58
Q

expected thyroid results in molar pregnancy

A

low TSH, high thyroxine

- due to negative feedback