Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Exam Revision > Haematology 1 > Flashcards

Haematology 1 Flashcards

1
Q

who gets acute lymphoblastic leukaemia

A

children

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

pathology of ALL

A

clonal proliferation of lymphoid precursors (most commonly B cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

symptoms of ALL

A

anaemia – SOB, palpitations, fatigue, insomnia, pale, cramps, dizziness
bleeding– easy bruising, bleeding gums, petechia, nose bleeds
infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

diagnosis of ALL

A

blood film + bone marrow aspirate

Diagnostic– immunophenotyping

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

how is ALL differentiated from AML

A

immunophenotyping

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

treatment of ALL

A

chemotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

who gets acute myeloid leukaemia

A

middle age- elderly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

pathology of AML

A

clonal proliferation of myeloid precursors (myeloblasts)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

symptoms of AML

A

anaemia
bleeding
infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is diagnostic of AML on bone marrow aspirate

A

AUER RODS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

treatment of AML

A

chemo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

who gets chronic myeloid leukaemia

A

middle-age elderly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

pathology of chronic myeloid leukaemia

A

PHILADELPHIA CHROMOSOME

BCR-ABL oncogene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

symptoms of CML

A

fever
weight loss
anaemia
massive splenomegaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

massive splenomegaly might make you suspect which cancer

A

Chronic myeloid leukaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

treatment CML

A

imatinib - tyrosine kinase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

who gets chronic lymphocytic leukaemia

A

elderly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

pathology of CLL

A

uncontrolled proliferation of B lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

symptoms of CLL

A

asymptomatic in early stages

anaemia, bleeding, infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

characteristic cells in CLL

A

smudge cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Treatment of CLL

A

chemo

22
Q

what is the bone marrow like in acute leukaemia

A

hypercellular – lots of immature cells

23
Q

philadelphia chromosome

A

chronic myeloid leukaemia

24
Q

auer rods

A

acute myeloid leukaemia

25
Q

immunomarker for myeloid precursors

A

CD33

26
Q

who gets Hodgkin lymphoma

A

young adults

27
Q

what is Hodgkin lymphoma associated with

A

EBV

28
Q

symptoms of Hodgkin lymphoma

A

painless lymph node enlargement
fever, night sweats, decreased weight
pruritus, fatigue, alcohol induced pain

29
Q

reed Sternberg cells

A

diagnostic of Hodgkin lymphoma

30
Q

alcohol induced pain + enlarged lymph nodes

A

Hodgkin lymphoma

31
Q

mirror image nuclei

A

reed Sternberg cells- Hodgkin lymphoma

32
Q

most common type of Hodgkin lymphoma

A

nodular sclerosing

33
Q

best prognosis hodgkin lymphoma

worst prognosis Hodgkin lymphoma

A

lymphocyte rich = best

lymphocyte depleted = worst

34
Q

Tx Hodgkin lymphoma

A

chemo

35
Q

Hodgkin lymphoma associated with lacunar cells

A

nodular sclerosing

36
Q

Hodgkin lymphoma associated with large numbers of reed sternberg cells

A

mixed cellularity

37
Q

who gets non-hodgkin lymphoma

A

> 40s

38
Q

symptoms of non-hodgkin

A

symmetrical painless lymphadenopathy
pancytopenia – anaemia/bleeding/infections
fever, weight loss

39
Q

what is an indicator of worse prognosis in non-hodgkin lymphoma

A

raised lactate dehydrogenase

40
Q

most common non-hodgkin lymphoma

A

diffuse B cell

41
Q

what is primary gastric lymphoma associated with

A

H. pylori

42
Q

african kid, history of EBV, tumour in jaw, 8:14 translocation

A

Burkitts lymphoma

43
Q

what does a lymph node feel like in lymphoma

A

rubbery, smooth, mobile, non tender

44
Q

immunomarkers positive for Reedsternberg cells

A

CD30

CD15

45
Q

Immunomarker for follicular non-hodgkin lymphoma

A

CD20

46
Q

what are plasma cells derived from

A

B cells

47
Q

what is multiple myeloma

A

clonal proliferation of plasma cells

- plasma cell malignancy in the bone marrow

48
Q

who gets multiple myeloma

A

elderly

peak age is 60

49
Q

what is produced in multiple myeloma

A

monoclonal antibodies

- usually IgG or IgA (paraproteins)

50
Q

what are Bence Jones Protein

A

free light chains (kappa or lambda) that are excreted in the urine

51
Q

pathogenesis of bone disease in multiple myeloma

A

clones produce IL 6 - inhibits osteoblasts + activates osteoclasts – bone destruction

52
Q

most common presenting complaint in multiple myeloma

A

back pain

Exam Revision (32 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions