Endocrine 3 Flashcards
what does a craniopharyngioma arise from
rathke’s pouch
what is a phaeochromocytoma
catecholamine producing tumour found in adrenal medulla
what conditions associated with phaeochromocytoma
MEN2
Neurofibromatosis
symptoms phaeochromocytoma
headache, sweating, tachycardia, palpitations, hypertension
treatment of pheochromocytoma
alpha blocker, then beta blocker pre surgery
- adrenelectomy
features Peutz-Jeghers
pigmentation on lips, oral mucosa, palms/soles
Pancreatic tumours
GI bleeds
renal cysts
bilateral renal carcinomas
phaeochromocytoma
pancreatic tumours
Von hippel Lindau
cafe au last spots, axillary freckling + pheochromocytoma
neurofibromatosis
investigation of phaeochromocytoma
24h urinary catecholamine collection
MIBG- sensitive
Kallmans syndrome
hypothalamus does not produce GnRh
ANOSMIA is a key feature
most common causes of pan-hypopituitarism
surgery
tumour
irradiation
features of panhypopituitarism
GH: obesity
LH/FSH: decreased libido, amenorrhoea, infertility, loss of secondary sexual characteristics
TSH: hypothyroidism
ACTH: low cortisol
symptoms of diabetes insipidus
polyuria
polydipsia
dehydration
what is central diabetes insipidus
posterior pituitary is not secreting enough ADH
- idiopathic
- congenital
- sheehans
- sarcoidosis
what is nephrogenic diabetes insipidus
kidneys are not responding to ADH
- congenital
- drugs
