Repro 2 Flashcards

1
Q

Do dogs and cats have seminal vesicles?

A

NO!

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2
Q

T/F: The size of the testes is generally not related to the size of the animal

A

True

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3
Q

Types of testicular cells

A
  • somatic cells

- germ cells

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4
Q

Interstitium (Inter-tubular) cells

A
  • Leydig cells
  • mast cells
  • CT
  • blood and lymph vessels
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5
Q

Seminiferous tubule (intra-tubular) cells

A
  • peritubular cells
  • Sertoli cells
  • germ cells
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6
Q

The Leydig cell is the site of _________ in the testis

A

androgen biosynthesis

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7
Q

These cells are also called supporting cells or the nurse cells

A

Sertoli cells

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8
Q

Sertoli cells have a ____ population in the seminiferous tubules - they stop dividing in early neonatal peroid

A

fixed

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9
Q

Tight junctions or the zonula occludens between adjacent Sertoli cells constitute the __________

A

blood-testis barrier

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10
Q

The blood-testis barrier divides the seminiferous epithelium into ______ and ________ compartments

A

basal and adluminal

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11
Q

The basal compartment has germ cells in ____

A

mitosis

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12
Q

The adluminal compartment has germ cells in ______

A

meiosis

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13
Q

During mitosis and meiosis in the testis, the dividing cells are connected by cytoplasmic bridges. Why?

A

Allows cells in the same cohort to communicate w/ each other and maintain synchrony of differentiation

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14
Q

What is spermiation?

A

process by which mature spermatids are released from Sertoli cells into the seminiferous tubule lumen prior to their passage to the epididymis

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15
Q

Residual bodies released from the sperm are phagocytosed by ___________

A

Sertoli cells

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16
Q

The sperm head consists of ….

A

nucleus and acrosome

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17
Q

The sperm tail consists of ….

A
  • connecting piece or neck
  • middle piece
  • principle piece
  • end piece
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18
Q

What is the arrangement of microtubules inside the tail of the sperm?

A

9 + 2 arrangement

9 doublets in a ring with one doublet in the center

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19
Q

T/F: Type A1 cells in the testis can revert to Type A0.

A

True

It reverts back to a stem cell for sperm production

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20
Q

What is spermatogenesis?

A

process in which spermatozoa are produced from male primordial germ cells by way of mitosis and meiosis

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21
Q

T/F: Waves of spermatogenesis is a concept in SPACE and the seminiferous epithelial cycle is a concept of TIME.

A

TRUE!

Note: this is often a T/F question on the test!!!!!!!!

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22
Q

T/F: The duration of spermatogenesis can not be altered by hormonal treatment, changes in temperature, etc.

A

True

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23
Q

T/F: The duration of spermatogenesis can be easily calculated

A

true

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24
Q

How is the duration of spermatogenesis calculated?

A

number of SE cycles x duration of one SE cycle

SE cycle = seminiferous epithelial cycle

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25
Q

What is the importance of cytoplasmic bridges present between developing male germ cells?

A

To maintain synchrony of differentiation

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26
Q

Factors regulating daily sperm production (4)

A
  • spermatogonial divisions
  • seasonal variations (environment)
  • cellular degeneration
  • hormones
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27
Q

_____________ determine the quantitative yield of sperm.

A

Spermatogonial divisions

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28
Q

Mitotic divisions controlled by ___________

A

germ cell/ Sertoli cell ratio

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29
Q

___________ can support only a fixed no. of germ cells

A

Sertoli cells

“ceiling effect” for sperm output

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30
Q

In summer months, male animals can experience ______ sperm output and sperm motility

A

decreased

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31
Q

One A1 spermatogonia can result in _____ sperm

A

512

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32
Q

Optimal thermal environment for normal spermatogenesis is _______, which is approx. 5 degrees C below body temperature

A

32 degrees C

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33
Q

Scrotum (5)

A
  • relatively thin skin
  • sweat glands and sebaceous glands
  • lack of subcutaneous layer of fat in the scrotal fascia
  • fibromuscular layer in the skin = Tunica Dartos
  • intracapsular position of large testicular blood vessels
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34
Q

Regulation of testicular temperature is accomplished by…

A

scrotum and pampiniform plexus

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35
Q

What fibromuscular lauer in the skin of the scrotum is sensitive to temperature changes?

A

tunica dartos

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36
Q

Describe the pampiniform plexus in the spermatic cord

A

The outer membrane of the testicular artery merges with the outer membrane of the testicular vein.
Inflowing arterial blood exchanges heat with outflowing venous blood.

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37
Q

Androgens (4)

A
  • support spematogenesis (maintaienance)
  • induce and maintain differentiation of male internal and external reproductive organs
  • induce secondary male sex characteristics
  • influence sexual behavior
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38
Q

In addition to functions, what do androgens promote? (3)

A
  • protein anabolism
  • somatic growth
  • regulate secretion of gonadotropins
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39
Q

Functions of FSH in males

A
  • synthesis of ABP, inhibin, activin, and aromatase

- increases LH receptors on Leydig cells

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40
Q

_____ in males leads to the synthesis and secretion of testosterone

A

LH

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41
Q

___ acts via Sertoli cells to stimulate spermatogenesis (initiation)

A

FSH

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42
Q

_____ increases the number of spematogonia and spermatocytes

A

FSH

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43
Q

________ regulates meiosis till pachytene stage

A

FSH

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44
Q

___ regulates Leydig cell numbers through androgen receptors in interstitial cells

A

FSH

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45
Q

_____ is necessary for the initiation of spermatogenesis, while _____ is necessary for the maintainance of spermatogenesis.

A

FSH; Testosterone

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46
Q

______ and __________ reduce FSH secretion

A

Inhibin and follistatin

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47
Q

_________ increases FSH secretion

A

Activin

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48
Q

Epithelium of the epididymis?

A

pseudostratified

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49
Q

The duct of the epididymis is lined by _________ muscle to facilitate sperm movement

A

smooth

50
Q

There are three kinds of cells in the epithelium of the epididymis. What are they/

A
  • basal
  • principal
  • clear
51
Q

What do basal cells do?

A

regenerate epithelium

52
Q

What do principal cells do?

A

absorb fluid and secrete substances such as alpha glycerophosphorylcholine, sialic acid, and carnitine

53
Q

The blood-epididymis barrier is formed by _______ junctions between principal cells and creates an anatomical, physiological, and immunological barrier.

A

tight

54
Q

What do clear cells do?

A

phagocytose cytoplasmic droplets

55
Q

Fluid within the epididymis duct has _______ to keep the spermatozoa quiscent

A

low oxygen tension

56
Q

T/F: Spermatozoa lack cytoplasm and organelles to perform normal cell functions

A

True

57
Q

Under anaerobic conditions, sperm utilize _________ that is present in abundance in the seminal plasma

A

fructose

58
Q

Functions of the epididymis

A
  • maturation of spermatozoa

- storage of spermatozoa

59
Q

T/F: Spermatozoa released from the seminiferous epithelium are fully mobile.

A

FALSE!!

They are immotile!!

60
Q

Where do spermatozoa acquire their motility?

A

in the epididymis

61
Q

T/F: The region of the epididymis where spermatozoa gain their fertilizing ability is species-specific.

A

True

62
Q

The major site for storage of spermatozoa is the ________

A

cauda epididymidis

63
Q

Smooth muscle fibers in the terminal part of cauda epididymidis and vas deferens contract __________

A

only during ejaculation

64
Q

How long can spermatozoa stored in the cauda retain fertilizing capacity?

A

several weeks

65
Q

On average, spermatozoa are transported through the epididymis in _______ (species dependent)

A

7 to 16 days

66
Q

Does increasing the frequency of ejaculation change the transit time through the epididymis?

A

Yes, it can reduce transit time by 10-20%. However the sperm may not have fully matured though

67
Q

This fibromuscular duct begins at the tail of the epididymis

A

ductus deferens

68
Q

In the ductus deferens, sperm are stored in the _________ portion and _________ movements propel the sperm

A

proximal; peristaltic

69
Q

Male Accessory Sex Glands

A
  • pair of ampulla (ductus deferens)
  • seminal vesicles
  • prostate gland
  • bulbourethral glands (Cowper’s glands)
  • urethral glands
  • preputial glands = modified sebaceous glands seen in rodents
70
Q

Seminal plasma, or accessoty gland secretions, are mixed with sperm and fluid from the cauda epididymis to form _____ at the time of ejaculation

A

semen

71
Q

Semen, the mixture of sperm and seminal plasma, contains what other things to help the sperm survive? (6)

A
  • electrolytes
  • fructose = energy source
  • ascorbic acid
  • vitamins
  • proteases
  • prostaglandins
72
Q

Main function of the seminal plasma?

A
  • provide an environment conducive to sperm survival within the female repro tract
  • prevent immunologic response in the female
73
Q

What might be the reason that there is a 1000-fold difference in the amount of citric acid in the seminal plasma than in the blood plasma?

A

may be involved in maintaining pH in the male and female tracts (vagina is acidic)

74
Q

What do the prostaglandins in the seminal plasma do in the female repro tract?

A
  • cause changes in cervical mucus

- cause uterine contractions to aid sperm transport

75
Q

Function of cholesterol and lipids in seminal plasma?

A

may help keep sperm quiscent until deposited into the female tract

76
Q

Why is there zinc in the seminal plasma?

A

inhibits sperm activation

77
Q

In which species does the male have penile spines on his caudally facing glans penis?

A

cat

78
Q

Two types of phallus

A
  • fibroelastic phallus

- musculocavernous/ vascular phallus

79
Q

The features of this phallus include:

  • small blood spaces
  • substantial amounts of fibroelastic tissue
  • sigmoid flexure
  • rapid erection
A

fibroelastic phallus

80
Q

What species are examples of fibroelastic phallus?

A
  • ruminants

- swine

81
Q

What species are examples of musculocavernous phallus?

A
  • stallion

- man

82
Q

The features of this phallus include:

  • large blood spaces
  • less fibroelastic tissue
  • slow erection
A

musculocavernous

83
Q

What causes the erection of the penis?

A

highly coiled arteries in the cavernous bodies that uncoil

This uncoiling allows rapid passage of large volumes of blood to fill and distend the sinuses

84
Q

Transport of sperm from cauda epididymidis to the female reproductive tract requires _________ and ___________

A

erection and ejaculation

85
Q

There are two stages to ejaculation. What are they?

A
  • emission

- ejaculation

86
Q

Function of testis and seminiferous tubules?

A

sperm production

87
Q

Function of collecting ducts?

A

transport and storage

88
Q

Function of epididymis?

A

transport, maturation, and ejaculation

89
Q

Function of vas deferens?

A

transport and ejaculation

90
Q

Function of seminal vesicles?

A

secrete thick liquid to transport sperm

91
Q

Function of prostate gland?

A

secretes thin alkaline solution to neutralise urine and female system

92
Q

Function of bulbourethral gland?

A

secretions may lubricate, flush out urine, or form a gelatinous plug

93
Q

In ejaculation, what happens during the emission stage?

A

sperm move from the cauda epididymidis and vas deferens into posterior urethra

94
Q

Emission is under what type of nervous regulation?

A

sympathetic autonomic

95
Q

This is the forceful expulsion of the semen from the penile urethra

A

ejaculation

96
Q

What is the function of penile papillae?

A

stimulate vagina

97
Q

Which hormone is necessary for the maintenance of penile papillae?

A

DHT

98
Q

____________ is necessary for accessory sex glands, while ____________ is essential for external genitalia

A

Testosterone; DHT

99
Q

Fertilization occurs in the ________ region of the oviduct

A

ampulla

100
Q

T/F: Oocytes live longer than spermatozoa.

A

FALSE!!!

Spermatozoa live longer than oocytes

101
Q

These structures of the oviducts contract and direct the ovum into the funnel-shaped opening of the oviducts

A

fimbriae

102
Q

Primary barries for sperm to reach ampulla from uterus/ vagina

A
  • mucus secreted by cervix
  • peristaltic muscle contractions in the oviducts are directed towards the uterus to transport ovum
  • transport of oviductal fluid by cilia towards uterus -against the direction which sperm need to go
103
Q

Transport of sperm in the female reproductive tract occurs in these two phase

A

rapid phase and slow phase

104
Q

General summary of the rapid phase

A

sperm (dead/alive) arrive at the site of fertilization within 2-10 minutes

105
Q

What is responsible for the rapid phase/

A
  • myometrial contractions initiated by oxytocin

- prostaglandins in the semen

106
Q

Why is there oxytocin for the myometrial contractions of the rapid phase?

A

Female secretes it as a result of coitus

107
Q

Spermatozoa that arrive within a few minutes after mating _____ fertilize the ovum

A

DO NOT

108
Q

Describe slow phase

A
  • Sperm reside for several hours in the cervical crypts, endometrial glands, and crypts in the uterotubal junctions following depostion
  • During this time, sperm undergo capacitation
109
Q

During capacitation: (3)

A
  • cholesterol coat is removed
  • channels are established in the acrocome
  • loss of ions such as zinc, calcium, magnesium, and sodium
110
Q

What permits the activation of acrosome?

A

removal of the cholesterol coat from the sperm surface

111
Q

What is essential for sperm penetration?

A

Channels in the acrosome that allow the release of pro-acrosin and hylauronidase

112
Q

Sperm acquire __________ when they come in contact with secretions from seminal vesicles

A

Glycodelin-S

113
Q

During slow migration in the female repro tract, sperm exchange Glycodelin-S with ________

A

Glycodelin-A and-F

secreted by estrogen-primed uterus and fallopian tube

114
Q

Function of Glycodelin-A and -F?

A

bound to head region of sperm to prevent premature sperm acrosome reaction

115
Q

After capacitation, there are 3 more steps in the slow phase. What are they/

A
  • changes in sperm cell surface proteins = Glycodelin-S to Glycodelin-A and -F
  • activation of ion channels on sperm surface
  • aquire motility
116
Q

Why is it essential for the activation of ion channels on sperm surface to occur?

A

change in pH from acidic to neutral as sperm migrate from cervix to uterus and fallopian tube

117
Q

____________ is essential for the successful transport of sperm

A

estrogen-primed uterus

118
Q

What 2 things allow for sperm transport in the slow phase?

A
  • uterine contrations

- motility of sperm acquired during the process of activation in the female tract

119
Q

T/F: The majority of sperm will reach the site of fertilization

A

FALSE!!

Majority WILL NOT!

120
Q

which chemical of uterine origin initiates lutelysis in most species?

A

PGF2-alpha

121
Q

In cows, ovulation occurs in _______ phase of the estrous cycle.

A

metestrus