Renal Uworld Flashcards
in whatMVA scenario is it okay to do bladder catheterization
on obvious pelvic fracture or blood from urethral meatus
what happens with inclusion body myositis
adult onset distal muscular weakness and atrophy
Tx for severe hypovolemic hypernatremia
isotonic 0.9% saline
rate for plasma sodium correction
1mEq/L/h
Tx for less severe hypovolemic hypernatremia
5% dextrose in 0.45% saline
cascade of decreased renal blood flow
RAAS activated. constricts efferent arteriole more than afferent to maintain GFR
what factors aggravate prerenal azotemia
decreased fluid intake, ACEI, aspirin
edema, hypoalbuminemia, elvated urine protein
nephrotic syndrome
what are the nephrotic syndromes
minimal change in kids
FSGS in adults and membranouse nephropathy in adults
Significant risk factor for membranous nephropathy
hep B
labs in Heb B related membranous nephropathy
low C3
protein excretion over 24 hours > 3g/day
all patients with epidural anesthesia require what
bladder catheterization from overflow incontinence
child with abdominal pain, lower extremity purpura, arthritis, hematuria
HSP, IgA mediated vasculitis of small vessels
arthralgias in IgA nephropathy (HSP)
knees and ankles, transient
renal involvement in HSP IgA nephropathy
microscopic hematuria, RBC casts, mild to mod proteinuria
slightly elevated Cr
what drugs cause interstitial nephritis
penicillins, cephalosporins, sulfonamides
clinical features of durg induced cephalosporins
patient will have fever, rash, arthralgias. can have darker urine (hematuria) sterile pyuria and eosinophiluria
Tx drug induced interstitial nephritis
remove causative agent
what drugs can you use for UTI in pregnancy
Nitrofurantoin
amoxicillin or augmentin
fosfomycin single dose
when to avoid TMP-SMX in pregnancy
1st and 3rd trimester
what not to Tx UTI with in pregnancy
fluoroquinolones
TMP-SMX
when to screen for aSx bacteriruia
12-16 weeks
What are common causes of early post op renal transplant dyfunction
ureteral obstruction
acute rejection
cyclosporine toxicity
vascular obstruction and ATN
Biopsy of kidney transplant 3 days later shows heavy lymphocyte infiltration and vascular involvement with swelling of intima? what is it and how to Tx?
acute rejection
IV steroids
Leukocye esterase
significant pyuria
nitrates
presence of enterobacteriaceae
expected dipstick for acute pyelonephritis
+ nitrites and leukocyte esterase
which drug is known to increase risk bladder CA
cyclophosphamide
how do you know if metabolic alkalosis is from vomiting or prior diuretic use
low urine Cl
metabolic alkalosis with high urine Cl and hypervolemia
primary hyperaldosteronism
cushing
ACTH production
pretibial myxedema
graves
edema in nephritis is caused how
decreased GFR and retention Na and water
vomiting causes what acid base
metabolic alkalosis because lose H+ and K+
how to decrease Ca oxalate stones
minimize Na intake
most common drug induced chrnoic renal failure in US
analgesic nephropathy
what happens in analgesic nephropathy
papillary necrosis and chronic tubulointerstitial nephritis
HTN, mild proteinuria, impaired concentration of urine
WBC casts are seen in
allergic interstitial nephritis
Adult with proteinuria and transient gross hematuria following acute pharyngitis
IgA nephropathy
asterixis causes
hepatic encephalopathy
uremic encephalopathy and hypercapnia
alkalotic urine
pH >5.5
RTA I
problem with H secretion into urine
infant with normal anion gap acidosis and failure to thrive
renal or GI acidosis likely
fanconi syndrome
glucosuria, aminoaciduria, phosphaturia
Renal tubular acidosis presentation in infants
growth failure
low serum bicarb
hyperCl
What drugs cause increased potassium
nonselective beta blockers ACEI, ARB digitalis cyclosporine heparin NSAIDs succinylcholine TMP-SMX
how does TMP SMX cause hyperkalemia
blocks epithelial Na channels in collecting tubules like amiloride does
can also cause small increase in Cr
how do ACEI work
dilate the efferent arterioles
signs of aspirin intoxication
tinnitus, fever and tachypnea
nausea, GI irritation
why acid base happens with aspirin OD
respiratory alkalosis
high respirations blowing CO2 off
then causes metabolic acidosis by uncoupling ox phos in mitochondira resulting in low HCO3 from high acid buildup
pH in aspirin OD
near normal from mixed acid base
resp alkalosis and metabolic acidosis
Tx aspirin OD
alkalinization or dialysis
skin rash, joint pains, myalgias and fatigue
past IV drug abuser
palpable purpura and HSM
UA show hematuria, RBC cast and proteinuria
BUN 30 Cr 2.0 C’ low and + anti HCV
mixed essential cryoglobulinemia
triad mixed essential cryoglobulinemia
palpable purpura, proteinuria, hematuria
HCV is related to what renal dysfunction
mixed essential cryoglobulinemia
pathogenesis contrast induced nephropathy
renal vasoconstriction and tubular injury
weight gain, facial edema HTN
4+ proteinuria no glucose in urine
no RBC and some fatty casts
greatest risk for?
hypercoagulability– nephrotic syndrome
nephrotic syndrome
proteinuria >4.5
hypoalbuminemia
edema
hyperlipidemia and lipiduria
why does nephrotic syndrome cause hypercoagulability
increased urinary loss antithrombin 3, altered levels protein C and S, increased platelet aggregation, hyperfibrinogenemia form increased hepatic synthesis and impaired fibrinolysis
complications nephrotic syndrome
protein malnutrition, iron resistent microcytic hypochromic anemia, increased infections
vit D deficiency
low complement levels with nephritic syndrome
postinfectious, lupus, MPGN or mixed cryoglobulinemia with HepC
What are depositied in mixed cryoglobulinemia
IC of IgM Ab and IgG anti Hep C Ab
Dx of mixed cryoglobulinemia
viral serology
Tx mixed cryoglobulinemia
plasmapheresis to remove cryoglobulins and immunosuppressants
ADAMTS13
thrombotic thrombocytopenia purpura
fever, microangiopathic hemolytic anemia, renal fialure and neuro signs.
what to check for in antiphospholipid Ab syndrome
anti cardiolipin Ab
clinical assocations with minimal change disease
NSAIDs and lymphoma
clinical associations with FSGS
african american and hispanics
obesity
HIV
heroin use
clinical associations with membranous nephropathy
adenocarcinoma
NSAIDs
hep B
SLE
clinical associations with Membranoproliferative glomerulonephritis
Hep B and C
lipodystrophy
clinical associations with IgA nephropathy
URI
Hepatorenal syndrome
severe liver cirrhosis can increase NO and cause systemic vasodilation causeing decreased vascular resistance and BP which will cause renal hypoperfusion which then activates RAAS
patients do not respond to fluids or removal of diuretics
Tx hepatorenal syndrome
splanchnic vasoconstrictores like midodrine, octreotide and norepi
FeNa
hepatorenal syndrome
patient came into hospital acidemic, 3 days later now mildy alkalemic
loop diuretic
electrolyte abnormality in addisons
hyponatremia
hyperkalemia
what drugs can induce urinary retention
TCAs
recurrent gross hematuria, proteinuria, sensorineural deafness with splitting of GBM
alports
causes of non anion gap acidosis
diarrhea fistulas acetazolamide RTA ureteral diversion iatrogenic
hyperkalemic RTA
type 4 RTA
seen in elderly with poorly controlled DM
needle shaped crystals in urine
Uric acid, need CT because radiolucent
complication of ureteral colic
ileus
oliguria, azotemia and elevated BUN/Cr >20 in post op patient
acute prerenal failure from hypovolemia
give IV fluids
when do you do renal and bladder US for children
infants
hypovolemic hypernatremic - not Sx
5% dextrose
euvolemic hypernatremia Tx
free water
amikacin is what type Antibiotic
aminoglycoside
which part of urethra when damaged causes inability to void
posterior
clinical presentation of interstitial cystitis
bladder pain with filling, relief with voiding
increased frequency, urgency
dyspareunia
Tx for recurrent interstitial cystitis
TCAs
analgesics
trigger avoidance
immediate Tx for hyperkalemia with EKG changes
Ca carbonate
Tx for hyperkalemia without EKG changes in patients with CKD
diuretics, cation exchange resins and hemodialysis
want emphasis on removing K
how to correct metabolic alkalosis in patient with bulimia
normal saline
comlication of Vesicoureteral reflux
renal scarring
HTN
bilateral abdominal masses
microhematuria
ADPKD
complications constipation in children
anal fissures, hemorrhoids, encopresis
enuresis/UTIs
vomiting
risk factors for constipation in children
initiation solid food and cows milk
toilet training
school entry
nephrosclerosis
hypertrophy and intimal medial fibrosis of renal arterioles
glomerulosclerosis
progressive loss gomerular capillary surface with glomerular and peritubular fibrosis
gross hematuria
bladder- cystitis or cancer
renal- glomerulonephritis
ureteral- nephrolithiasis
prostate-BPH
gross hematuria with normal RBC
extra-glomerular
renal complication sickle cell trait
painless hematuria from renal papillary necrosis or ischemia
or
inability to concentrate urine from vasa rectae damage and distal renal tubular acidosis
renal medullary cancer
GU complications DM
erectile dysfunction and retrograde ejaculation
decrased libido and dysparenunia in women
–Neurogenic: decreased ability to sense bladder causing incomplete emptying and decreased urination
recurrent UTIs and overflow incontinence
can get diabetic nephropathy
in a cocaine abuser, greatest GU complication
acute renal failure from rhabdomyolysis
urine dip + for blood but no RBC on microscopy
myoglobin in the urine from muscle breakdown
signs of acute renal injury from diuretic therapy
elevated Cr
elevated BUN with ratio>20
elevated anion gap
presenting features of post strep glomerulonephrtiis
periorbital swelling, hematuria and oliguria
Complement levels in post strep glomerulonephritis
low
WBC cast
tubulo interstitital nephritis
RBC casts
post strep glomerulonephritis
low complement levels
post strep GN
membranoproliferative GN
goal in patient with EKG findings and hyperkalemia. also has Hx of active coronary artery disease
give insulin with glucose
beta 2 agonists could cause angina and tachycardia
isolated proteinuria in child
if around 1-2+ and all other values normal
repeat urine dip on 2 subsequent occasions
glomerulonpehritis: post strep vs IgA
post strep happens 10-21 days post infection
IgA 5 days post infection
post obstructive diuresis
obstruction causing difficulty urinating and occasionally having intermettent episodes of high volume urination because obstruction is temporarily relieved
bleeding at end of urination
prostatic or bladder cause
post seizure angion gap metabolic acidosis
results from lactic acidosis
Tx lactic acidosis in seizure patient
observation and repeat Chem P in 2 hours to check acidosis
Tx uric acid stones
hydration, alkalinization with potassium citrate and low purine diet
most common cause of AA amyloidosis in US
rheumatoid arthritis
envelope shaped stones
Ca oxalate
hyperPTH likely to have what kidney stones
calcium phosphate
signs BPH but also worsening Cr
do a renal US to look for hydronephrosis secondary to obstruction
signs of cyanide toxicity
flushing, cyanosis headache, altered mental status, seizures arrhythmias tachypnea and pulmonary edema abdominal pain, nausea, vomiting metabolic acidosis from lactic acidosis
how does Na nitroprusside work
vaso and veno dilates
Tx for cyanide toxicity
Na thiosulfate
if K is greater than 6.5 and have EKG changes
Ca gluconate
Dx for posterior urethral injury
retrograde urethrogram
what happens to BUN and Cr in pregnancy
decrease because renal plasma flow and GFR increase
girl who was potty trained starts wetting bed and drinking alot uncontrollably
Diabetes I
metabolic effect of chlorthalidone
hyperglycemia
thiazide diuretic
how do thiazides cause hyperglycemia
impair insulin release from pancreas and glucose utilization in peripheral tissues
what diseases haveCa oxalate stones
fat malabsorption syndromes
increase absorption of oxalate
urine Ca Cr ratio in familial hypocalciuric hypercalcemia
lab finding in acude tubular necrosis
muddy brown casts
large blood on UA but none on microscopy
rhabdomyolysis
urinary cyanide nitroprusside test
cystine stones
hexagonal crystals stones
cystine stones
patient is becoming septic. discontinue what metabolic drug
metformin because can cause lactic acidosis in AKI
effect of beta agonists on K
decrease it
HIV kidney disease
FSGS
when given metabolic acidosis with high anion gam if given osmolality (osmolal gap) >10 high
ethylene glycol
methanol
propylene glycol
high anion gap metabolic acidosis with rectangular envelop shaped Ca oxalate crystals!!!
ethylene glycol
methylene glycol can lead to
blindness
CI to using succinylcholine in rapid induction
hyperkalemia
SLE
HA, photosensitive skin
thrombocytopenia
glomerulonephritis with low C3 and C4
HUS
usually with shiga toxin E coli making microangiopathic hemolytic anemia, thrombocytpenia and renal failure
Tx severe Sx hypercalcemia
IV normal saline
long term management hypercalcemia of malignancy
bisphosphonates
what med helps to pass a idney stone
tamsulosin
nephrotic syndrome increases risk for what
atherosclerosis. because low oncotic pressure causes holding onto cholesterol and TG to keep pressure
steril pyruia and WBC casts
tubulointerstitial nephritis
Tx for dehydration in elderly
IV crystalloid- usually normal saline
risk of correcting hyponatremia too quickly
osmotic demyelination
pH PaCO2 HCO3 K and Cl in oyloric stenosis
inc pH, PaCO2, HCO3
dec K and Cl
what causes hypovolemic hyponatremia
acute blood loss, renal (diuretics) diarrhea and vomiting and primary adrenal insufficiency
Heb B GN
membranous nephropathy
lymphoma renal disease
minimal change
adenocarcinoma related renal pathology
membranous nephropathy
drug therapy to preven calcium stones
thiazides to lower Ca excretion
Tx for recurring uric acid stones
allopurinol
bleeding with chronic renal failure
common. from platelet dysfunction
BT is prolonged
normal aPTT and PT
abrnomal bleeding in chronic renal failure
from platelet dysfunciton.
normal count
normal PT and PTT
long BT
how does DDAVP help with platelet dysfunction
increases release of factor VIII, Vw multimers from endothelial sites
nephrotic range proteinuria with hematuria
membranoproliferative GN
finding in membranoproliferative GN
dense intramembranous deposits that stain for C3
dense deposit disease
what causes memrbanoproliferative GN
IgG Ab for C3 “nephritic factor” directed against C3 convertase
leads to persistent C’ activation and kidney damage
what are the IC GN
SLE, post strep
cell mediated injury Glomerulonephritis
crescenteric
what are the non immunoogic kidney GN
diabetic nephropathy
HTN nephropathy
Tx uncomplicated cystitis in non pregnant
nitrofurantoin
TMP-SMX
fosfomycin
Tx complicated cystitis
fluoroquinolones
Tx outpatient pyelonephritis
fluoros
Tx inpatient pyelo
IV fluoro or aminoglycoside and ampicillin
hyponatremic
euvolemic
after bolus of saline and urine Na increases while serum Na does not change
SIADH
why in alcoholics is K hard to correct
hypoMg
Tx SIADH with moderate Sx of confusion
hypertonic saline
Tx severe SIADH having seizures
bolus hypertonic saline with Vasopressin antagonists like conivaptan
first renal abnormality in diabetic nephropathy
glomerular hyperinfiltration
first renal change that can be quantified for diabetic nephropathy
thickeness of GBM
what cuase crystal induced acute kidney injury
acyclovir sulfonamides MTX ethylene glycol protease inhibitors
what is crystal induced acute kidney injury
crystal obstruction and direct renal tubular toxicity
Tx for cushing like syndrome
spironolactone, aldosterone antagonist
cause of potter sequence
posterior urethral valve
Renal vein thrombosis is a complciation of what
nephrotic syndrome from loss of antithrombin III
patient with nephropathy but on salt restriction and diuretics then suddenly develops severe sided pain with fever and gross hematuria
membranous nephropathy causing renal vein thrombosis
most sensitive test to screen for diabetic nephropathy
random urine for microalbumin/Cr ratio
electrolyte abnormality in TB
well if causing primary adrenal insufficiency then can cause hyperkalemia, hypoglycemia and also will cause decreased aldosterone secretion so lose Na save K and H causing normal anion gap with hyperkalemia and hyponatremic metabolic acidosis