OB Stepup Flashcards
how is sgestational age calculated
first day of LMP + 7 days
minus 3 months+1 year
when can teratogens cause abnormal organ function
between 2 and 12 weeks
when is surfactant produced
26 weeks
CV changes in mom during pregnancy
CO increases 40%
systolic murmur from CO
inc O2 demand
dec BP
Resp changes in mom during pregnancy
decreased in RV, FRC, and ERV
O2 consumption increases 20%
tidal volum einc 40%
pCO2 decreases because of increased minute ventilation stimulated by progesterone
Renal changes in mom during pregnancy
increased RBF and GFR
dec DUN and Cr
Inc renal loss HCO3 to compensate for respiratory alkalosis
endocrine changes in mom during pregnancy
nondiabetic hyperinsulinemia with assoc mild glucose intolerance
production human placental lactogen contributes to glucose intolerance
fasting TG increase
cortisol increases
TBG and total T4 increase
TSH decreases slightly during early pregnancy
heme changes during pregnnacy
hypercoagulable state
increased RBC production
Hct dec from inc blood volume
GI changes during pregnancy
increased salivation
decreased gastric motility
ideal weight gain for pregnant women BMI
28-40
ideal weight gain for pregnant women BMI
25-35
ideal weight gain for pregnant women BMI >26
15-25
caffeine increases risk for what during pregnancy
increased risk spontaneous abortion
why limit fish during pregnancy
methylmercury contamination
daily caloric intake during pregnancy
2500 kcal
screening labs at first visit of pregnancy
CBC blood Ab and Rh testing pap smear Gon/chalmydia testing UA RPR or VDRL rubella Ab Hep BsAg HIV screening
when do you do the quad screen
16-18 weeks
when do you do US dating for age and fetal anomalies
18-20 weeks
when is the gestational DM test
24-28 weeks
when do you do GBS sreening
32-37 weeks
Why to do amniocentesis
abnormal quad screen
women >35 years
risk Rh sensitization
0.5% risk spont abortion
when do you perform amniocentesis (date)
16 weeks
measures amniotic AFP and can do karyotype
at what date do you do chorionic villus samlping
transabdominal or transcervical aspiration of tissue 9-12 weeks gestation
detects chromosomal abnormalities
indications for chorionic villus sampling
early detection of chromosomal abnormalities in higher risk patients
when is percutaneous umbilical blood sampling
blood sampling from umbilical vein after 18 weeks gestation to look for chromosomal defects, fetal infection and Rh sensitization
What are leopold maneuvers
external abdominal exam to determine fetal presentation
what do you measure for full integrated test in 1st trimester
PAPP-A and NT
labs in downs for full integrated test
dec PAPP-A and icnreased nucal translucency
labs for downs in quad screen
dec AFP
dec estriol
inc hCG
inc Inhibin A
labs for edwards in quad screen
dec AFP
very dec estriol
very dec hCG
normal inhibin A
labs for patau trisomy 13 in quad screen
normal AFP
normal estriol
normal hCG
normal inhibin A
labs for patau trisomy 13 on full integrated test
very dec PAPP-A and increased nuchal translucency
labs for edwards on full integrated test
very dec PAPP-A and increased nuchal transluceny
high levels maternal AFP between 16-18 weeks assoc with
neural tube defects or multiple gestations
low levels maternal AFP between 16-18 weeks assoc with
trisomy 21 and 18
risk factors gestational DM
>25 years old obesity prior polyhydramnios recurrent abortions prior stillbirth prior macrosomia HTN african or pacific islander corticosteroid use PCOS
what should fasting glucose be in pregnancy
new onset DM in first trimester
nongestational!!!
pregnant patient failing non pharmacologic methods to control gesttational DM
insulin
what is normal 1 hr glucose tolerance test
give 50g glucose 1 hour later should be
3 hr glucose tolerance test
carbo load 3 days
fasting glucose measured
100 g given then measure at 1 2 and 3 hours
abnormal is fasting >95 1 hr >180 2 hr >150 3 hr >140 Need 2 of the above values to be considered gestational DM
when to check gestational DM
24-28 weeks
complications gestational DM
macrosomia polyhydramnios delayed pulmonary maturity uteroplacental insufficiency IUGR delayed neurologica maturity fetal RDS hypoglycemia hypoCa
Dx for DM I
anti insulin and anti islet cell Ab
in mom with DM and is pregnant do what in third trimester
give corticosteroids for fetal lung maturation
fetal cardiac anomalies associated with maternal DM
transposition tetralogy neural tube defects sacral agenesis renal agenesis polyhydramnios macrosomia IUGR intrauterine fetal demise
what is preeclampsia
pregnancy induced HTN with proteinuria and edema after 20 weeks gestation
risk factors preeclampsia
HTN nulliparity prior Hx preeclampsia multiple gestation vascular disease chronici HTN or renal disease DM obesity african american heritage
signs Sx preeclampsia
edema in hands and face rapid weight gain HA epigastric pain visual disturbances hyperreflexia BP >140/90
UA in preeclampsia
2+ proteinuria on dipstick
>300 mg protein/24 hr
CBC preeclampsia
dec platelets
normal or inc Cr
increased aLT AST
dec GFR
cure for preeclampsia
delivery
which BP meds do you not use in preeclampsia
ACEI or ARB
want to maintain what BP in preeclampsia
90
what meds do you use in severe preeclampsia
labetalol
IV MgSO4 for seizure proph
continue postpartum
Rx for preexisting HTN in pregnant women
lavetalol or methyldopa
long acting CCB as sexond agent
Complications preeclampsia
eclampsia, seizure, stroke, IUGR, pulmonary edema, maternal organ dysfunction, oligohydramnios, preterm delivery, hemolysis, elevated liver enzymes, low platelets, abruptio placenta, renal insufficiency, encephalopathy, DIC
what is eclampsia
maternal seizures that can be fatal
Signs Sx eclampsia
HA
scotoma visual disturbances, upper abdominal pain preceding seizures
Tx exlampsia
delivery
MgSO4 and IV diazepam for seizure
O2 and BP control with labetolol and hydralazine
continue MgSO4 for post 48 hours
anticonvulsants with pregnancy
kept on meds but supplemented with folate
what is associated with severe maternal asthma
preeclampsia, spontaneous abortion, intrauterine fetal demise and IUGR
Tx mild persistent asthma in pregnangy
short acting Beta agonist and low dose inhaled corticosteroid
Tx mod persistent asthma in pregnangy
med dos inhaled corticosteroid or low dose + long acting beta
Tx severe persistent asthma
high dose inhaled corticosteroid plus long acting beta
complications maternal asthma
increased risk preeclampsia, spontaneous abortion, Intrauterine fetal death
IUGR
Tx hyperemesis gravidarum
avoidance large meals
adequate hydration
pyridoxine and doxylamine
what causes morning sickness
increase hCG or imbalance P and E
Dx DVT in pregnancy
doppler and US studies
Tx DVT in pregnangy
IV heparin to maintain PTT 2x normal or LMWH to keep anti-factor Xa levels within 0.5-1.2 4 hours post infection
DVT in pregnancy, discharged on
LMWH
try to discontinue 24-36 hrs prior to delivery
why not use warfarin in pregnancy
teratogenic
but can use breast feeding
how long are anticoagulants continued post partum if patient had DVT during pregnancy
6 weeks
and wait at least 6 hours since delivery to prevent severe hemorrhage
Tx UTI in pregnancy
amox
nitrofurantoin
cephalexin x3-7 days
why not use fluoroquinolones in pregancy
teratogenic
fetal effects from maternal marijuana
IUGR and prematurity
fetal risks of maternal cocaine use
abruptio placentae IUGR prematurity facial abnormalities delayed intelectual development fetal demise
fetal risks of ethanol use during pregnancy
fetal alcohol syndrome- mental retardation, IUGR, sensory and motor neuropathy, facial abnormalities
psontaneous abortion
Intrauterine fetal demise
fetal risks of maternal use of opioids
prematurity, IUGR meconium aspiration, neonatal infecitons, narcotic withdrawl
fetal risks of maternal use of stimulants
IUGR congenital heart defects, cleft palate
fetal risks of maternal use of tobaccco
spont abortion prematurity IUGR intrauterine fetal demise impaired intellectual development higher risk neonatal respiratory infections
maternal risk factors for using tobacco during pregnancy
abruptio placentae, placenta previa, PROM
fetal risks of maternal use of hallucinogens
developmental delays
ACEI teratogenic effects
renal abnormalities and decreased skull ossification
Aminoglycoside teratogenicity
CN VIII damage (hearing) skel abnormalities, renal defects
carbamazapine teratogenicity
facial abnrmalities, IUGR, mental retardation, CV abnormalities
neural tube defects
DES teratogenicity
vaginal and cervical cancer later in life
fluoroquinolone teratogenicity
cartilage abnormalities
phenobarbital teratogenicity
neonatal withdrawal
phenytoin teratogenicity
facial abnormalities, IUGR, mental retardation, CV abnormalities
retinoids teratogenicity
CNS abnormalities, CV abnormalities, facial abnormalities, spont abortion
sulfonamides teratogenicity
kernicterus
tetracycline teratogenicity
skeletal abnormalities, limb abnormalities, teeth discoloration
thalidomide teratogenicity
limb abnormalities
valproic acid teratogenicity
neural tube defects
facial abnormalites
CV abnormalities
skeletal issues
warfarin is assoc with what teratogenic effect
dandy walker malformation
TORCH
toxo other: varicella, parvo, GBS, Chlamydia, gonn Rubella, rubeola, RPR Cytomegalovirus Herpes/hepatitisB, HIV
congenital toxo signs
hydrocephalus, intracranial calcifications, chorioretinitis, microcephaly
seizures
spont abortion
Dx toxo in pregnancy
amniotic fluid PCR for toxo and srum Ab sscreening
Tx for toxo infection in mom
pyrimethamine, sulfadiazine, folinic acid
avoid gardening, raw meat, cat litter and unpasteurized milk
congenital rubella
blueberry muffin baby
IUGR, deafness, CV abrnomalities, vision isssues, CNS problems, hepatitis
screeningmaternal rubella
early prenatal IgG screening
if mom contracts rubella during pregnancy
no Tx and no benefit from Ig
fetal effects of rubeola (measles) infection
increased risk prematurity
IUGR
spont abortion
high risk neonatal death if transmission occurs
Dx rubeola or measles in pregnancy how
IgM or IgG Ab in mom after rash develops
Tx if mom has rubeola during pregnancy
Ig to mom
not vaccine because live attenuated
Fetal risks of maternal syphilis infection
neonatal anemia, deafness, HSM, pneumonia, hepatitis, osteodystophy, rash and hand foot desquamation
25% death
Dx maternal syphilis infection
early prenatal RPR or VDRL screen
confirm with FTA-ABS
Tx maternal syphilis infection
penicillin for mom and baby if needed
effcts of CMV infection on fetus
IUGR, chorioretinits, CNS problems
mental retardation, vision issues, deafness, hydrocephalus, seizures, HSM
Dx of CMS infection during pregnancy
mono like illness
IgM screening or PCR of baby in first few weeks
Tx for CMV infection in pregnany
no Tx
gangciclovir after once baby is born
good hygiene reduces transmission
fetal effects of maternal herpes infection
increased risk prematurity
IUGR and spont abortion
high risk death
CNS problems
Tx for herpes maternal infection
delivery by C section to avoid transmission
acyclovir maybe in infants