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Renal Tumors Flashcards

1
Q

Renal papillary adenoma

Benign vs malignant

A

Malignant >1cm

Benign <5mm (.5cm)

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2
Q

Wilm’s tumor

Disease association

A

WAGR syndrome, retardation, genital anomalies, WT1 PAX6 on Ch 11!!!!, Denys-Drash Syndrome, Pseudohermaphroditism, WT1 gene, Beckwith-Wiedemann syndrome: organomegaly, WT2 gene

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3
Q

Angiomyolipoma

Disease association?

A

Tuberous sclerosis (multiple masss)

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4
Q

Magnesium ammonium phosphate stone

Cause, stone type

A

Stivite stone, PROTEUS, alkaline urine, staghorn calculi (triple stone), colorless 3 to 6 sided prism, “coffin lids”

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5
Q

Urothelial carcinomas of Renal Pelvis

A

Hydronephrosis, hematuria

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6
Q

Hobnail cells are seen in…

A

Collecting Duct Carcinoma

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7
Q

Most painful renal calculi?

A

Small stones (2-3 mm)

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8
Q

Papillary carcinoma

A

Has papillary projections, Calcium deposition call Somoma bodies

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9
Q

Collecting Duct carcinoma

A

Aggressive tumor, HOBNAIL type cells, desmoplastic (fibrotic) stroma, neoplastic ducts

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10
Q

Cysteine Stone

A

Hexagonal, laminated, low pH

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11
Q

hexagonal, laminated stones, low pH

A

Cystine stone

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12
Q

Renal Cell Carcinoma

MC cause

A

Tobacco

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13
Q

Uric acid crystals precipitate in acidic or basic urine?

A

Acidic (5.5)

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14
Q

VHL syndrome is associated with…

A

Renal Cell Carcinoma

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15
Q

Renal Cell Carinoma

Mets sites

A

Lung and bones

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16
Q

Wilms Tumor

Histology

A

Triphasic, blastemal, stromal and epithelial cells

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17
Q

Foamy macrophages are a characteristic finding in which type of reaction?

A

Acute transplant reaction

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18
Q

Radiolucent, flat four sided (rhomboid) crystal

A

Uric acid crystal

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19
Q

Renal papillary adenocarcinoma

A

Benign, found at autopsy

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20
Q

Renal Cell Carinoma

Gene defect and disease association

A

Von hippel lindau, Chr 3 VHL gene

21
Q

Renal Cell Carinoma

MC type

A

Clear cell type

22
Q

Papillary carcinoma

Chr abnormalities

A

7,16,17, and y

Familial: 7

23
Q

Ca oxolate stone

A

Small refractile octahedron

24
Q

Xp11 translocation carcinoma

Morphology

A

Papillary architecture, clear cytoplasm

25
Tuberous sclerosis is associated with...
Angiomyolipoma
26
Chromophobe carcinoma Stain
Hale's colloidal iron
27
Hyperacute transplant reaction is what type of reaction?
Ag-ab rxn
28
Renal Cell Carinoma VHL signs
Hemangioblastoma (cerebellum and retina) and cysts
29
Renal Cell Carcinoma
From renal tubular epithelial, costovertebral pain, palpable mass, hematuria
30
Angiomyolipoma
One large mass, thick walled vessels, muscle and fat components, cerebral cortex
31
Small colorless refractile octahedron
Ca Oxolate
32
3 to 6 sided prism, "coffin lid"
Magnesium ammonium phosphatee stone
33
Acute transplant reaction
Cellular: Tercel mediated, responds to immunosuppressive therapy Humoral: ab mediated, neutrophils, fibrin, thrombi, foamy macrophages, complement deposition, tx: B cell depleting agents
34
Hyperacute transplant reaction
Min to hrs, cyanosis, mottled, flaccid, fibrin thrombi and WBC
35
Hale's colloidal iron is a good stain for...
Chromophobe carcinoma
36
Acute transplant reaction is what type of reaction?
Cellular: T cell mediation Humoral: ab mediated
37
Chromophobe carcinoma
Halo around nucleus (pernuclear clearing), solid sheets, distinct cell borders (membrane)
38
Renal Cell Carinoma Disease association
Von hippel lindau
39
Renal fibroma (hamartoma)
Within pyramids, benign, found at autopsy
40
Large branching stone
Staghorn calculi
41
Wilm's tumor Epidemiology
CHILDHOOD (bilateral)
42
Uric acid stone shape
Flat four sided (rhomboid) shape
43
Xp11 translocation carcinoma Epidemiology
Young people
44
Oncocytoma
Benign, Stellate scar, mahogany, pink cytoplasm, oncocytic cells
45
Xp11 translocation carcinoma Gene defect
TFE3
46
2-5 yr old with renal mass
Wilms tumor
47
Strivite Stone
Magnesium ammonium phosphate stones
48
Angiomyolipoma Tuberous sclerosis gene defect?
TSC1 or 2
49
Chronic transplant reaction
Months to yrs, inc Cr, hyalinization of glomeruli, interstitial fibrosis, tubular atrophy DOES NOT RESPOND TO IMMUNOSUPPRESSION

Renal disease (6 decks)

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