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Renal disease > Renal Tumors > Flashcards

Renal Tumors Flashcards

1
Q

Renal papillary adenoma

Benign vs malignant

A

Malignant >1cm

Benign <5mm (.5cm)

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2
Q

Wilm’s tumor

Disease association

A

WAGR syndrome, retardation, genital anomalies, WT1 PAX6 on Ch 11!!!!, Denys-Drash Syndrome, Pseudohermaphroditism, WT1 gene, Beckwith-Wiedemann syndrome: organomegaly, WT2 gene

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3
Q

Angiomyolipoma

Disease association?

A

Tuberous sclerosis (multiple masss)

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4
Q

Magnesium ammonium phosphate stone

Cause, stone type

A

Stivite stone, PROTEUS, alkaline urine, staghorn calculi (triple stone), colorless 3 to 6 sided prism, “coffin lids”

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5
Q

Urothelial carcinomas of Renal Pelvis

A

Hydronephrosis, hematuria

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6
Q

Hobnail cells are seen in…

A

Collecting Duct Carcinoma

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7
Q

Most painful renal calculi?

A

Small stones (2-3 mm)

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8
Q

Papillary carcinoma

A

Has papillary projections, Calcium deposition call Somoma bodies

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9
Q

Collecting Duct carcinoma

A

Aggressive tumor, HOBNAIL type cells, desmoplastic (fibrotic) stroma, neoplastic ducts

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10
Q

Cysteine Stone

A

Hexagonal, laminated, low pH

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11
Q

hexagonal, laminated stones, low pH

A

Cystine stone

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12
Q

Renal Cell Carcinoma

MC cause

A

Tobacco

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13
Q

Uric acid crystals precipitate in acidic or basic urine?

A

Acidic (5.5)

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14
Q

VHL syndrome is associated with…

A

Renal Cell Carcinoma

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15
Q

Renal Cell Carinoma

Mets sites

A

Lung and bones

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16
Q

Wilms Tumor

Histology

A

Triphasic, blastemal, stromal and epithelial cells

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17
Q

Foamy macrophages are a characteristic finding in which type of reaction?

A

Acute transplant reaction

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18
Q

Radiolucent, flat four sided (rhomboid) crystal

A

Uric acid crystal

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19
Q

Renal papillary adenocarcinoma

A

Benign, found at autopsy

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20
Q

Renal Cell Carinoma

Gene defect and disease association

A

Von hippel lindau, Chr 3 VHL gene

21
Q

Renal Cell Carinoma

MC type

A

Clear cell type

22
Q

Papillary carcinoma

Chr abnormalities

A

7,16,17, and y

Familial: 7

23
Q

Ca oxolate stone

A

Small refractile octahedron

24
Q

Xp11 translocation carcinoma

Morphology

A

Papillary architecture, clear cytoplasm

25
Q

Tuberous sclerosis is associated with…

A

Angiomyolipoma

26
Q

Chromophobe carcinoma

Stain

A

Hale’s colloidal iron

27
Q

Hyperacute transplant reaction is what type of reaction?

A

Ag-ab rxn

28
Q

Renal Cell Carinoma

VHL signs

A

Hemangioblastoma (cerebellum and retina) and cysts

29
Q

Renal Cell Carcinoma

A

From renal tubular epithelial, costovertebral pain, palpable mass, hematuria

30
Q

Angiomyolipoma

A

One large mass, thick walled vessels, muscle and fat components, cerebral cortex

31
Q

Small colorless refractile octahedron

A

Ca Oxolate

32
Q

3 to 6 sided prism, “coffin lid”

A

Magnesium ammonium phosphatee stone

33
Q

Acute transplant reaction

A

Cellular: Tercel mediated, responds to immunosuppressive therapy
Humoral: ab mediated, neutrophils, fibrin, thrombi, foamy macrophages, complement deposition, tx: B cell depleting agents

34
Q

Hyperacute transplant reaction

A

Min to hrs, cyanosis, mottled, flaccid, fibrin thrombi and WBC

35
Q

Hale’s colloidal iron is a good stain for…

A

Chromophobe carcinoma

36
Q

Acute transplant reaction is what type of reaction?

A

Cellular: T cell mediation
Humoral: ab mediated

37
Q

Chromophobe carcinoma

A

Halo around nucleus (pernuclear clearing), solid sheets, distinct cell borders (membrane)

38
Q

Renal Cell Carinoma

Disease association

A

Von hippel lindau

39
Q

Renal fibroma (hamartoma)

A

Within pyramids, benign, found at autopsy

40
Q

Large branching stone

A

Staghorn calculi

41
Q

Wilm’s tumor

Epidemiology

A

CHILDHOOD (bilateral)

42
Q

Uric acid stone shape

A

Flat four sided (rhomboid) shape

43
Q

Xp11 translocation carcinoma

Epidemiology

A

Young people

44
Q

Oncocytoma

A

Benign, Stellate scar, mahogany, pink cytoplasm, oncocytic cells

45
Q

Xp11 translocation carcinoma

Gene defect

A

TFE3

46
Q

2-5 yr old with renal mass

A

Wilms tumor

47
Q

Strivite Stone

A

Magnesium ammonium phosphate stones

48
Q

Angiomyolipoma

Tuberous sclerosis gene defect?

A

TSC1 or 2

49
Q

Chronic transplant reaction

A

Months to yrs, inc Cr, hyalinization of glomeruli, interstitial fibrosis, tubular atrophy
DOES NOT RESPOND TO IMMUNOSUPPRESSION

Renal disease (6 decks)

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