Renal Pharmacokinetics Flashcards
1
Q
When to call PharmD for renal dosing?
A
Age > 65
Crea > 1.5
2
Q
Normal range for serum creatinine?
A
.8 - 1.2
3
Q
Cockcroft-Gault Equation
A
((140-age) x weight (kg)) / 72 x SCr
For female, multiply by .85
4
Q
How to calculate weight
A
50 kg + 2.3 kg per inch over 5 ft.
5
Q
Examples of nephrotoxic drugs
A
NSAID (afferent arteriole constriction) Aminoglycosides (kill cells in PCT) Heavy metals (injures PCT) Radiocontrast (acute tubular necrosis) Antifreeze (ethylene glycol)
6
Q
How does renal dosing usually affect the loading dose?
A
It is normally the same
7
Q
2 ways to for renal dosing.
A
Reduced amount, same interval. Maintains constant blood level.
Same dose, longer interval. good for drugs with long half-lives.
8
Q
At what GFR is renal dosing indicated?
A
< 50
9
Q
Abx with no renal dosing for CKD
A
Z-pack
Ceftriaxone (rocephin)
Moxifloxacin
Doxy
