Renal function Flashcards
Kidney function
remove waste, control nutrient loss, essential to water and electrolyte balance and acid base balance.
Filtration
plasma is filtered from blood
Average person renal blood flow
600mL/min
Glomerulus
substances <70 kilodaltons pass through (selective by size) ultrafiltrate of blood. Normally only glucose and ions can pass through filter.
Capillary endothelial cells
in kidneys they have larger openings (fenestrated) is nonselective
Basement membrane
only lets things <4nanometers. has a net negative charge so only positive ions can pass.
podocytes
epithelial cells, inner lining of Bowmans capsule. are woven together to make filtration slits. Phagocytose any molecules that get stuck in filtration barrier
hydrostatic pressure
60mmHg
capsular hydrostatic pressure
20mmHg
blood colloidal pressure
30mmHg
Juxtaglomerular cells
specialized cells at afferent arteriole that regulates pressure
macula densa
specialized cells at distal tubule that work with the juxtaglomerular cells
juxtaglomerular apparatus
the two cells work together and respond to change in blood pressure (generally from sodium)
angiostensin II
increases sodium reabsorption to increase water reabsorption, causes an increase in blood pressure. Sends thirst signals to the brain and encourages aldosterone and ADH secretion
aldosterone
hormone regulating sodium reabsorption in distal tubule
ADH
hormone regulating water reabsorption in collecting duct