Renal Clearance

Question 1

define clearance

Answer 1

the rate at which plasma is cleared of a particular substance

Question 2

what is creatinine

Answer 2

end product of creatine

Question 3

what is amount of creatinine in body proportional to?

Answer 3

to muscle mass

Question 4

what is inulin?

Answer 4

fructose polymer

Question 5

what does inulin require and if used in renal clearance how does it achieve what is required?

Answer 5

• requires infusion
• if in renal clearance, infused intravenously

Question 6

what is the equation for rate of clearance and define each symbol

Answer 6

UV/P

U = the concentration of the substance in urine

V = the rate of urine production

P = the concentration of the substance in the plasma

Question 7

what is the normal creatinine clearance in the average healthy female and average healthy male (they are different)

Answer 7

female: 88 - 128 mL/min

Male: 97 - 137 mL/min

Question 8

what does plasma flow equal (theoretically)?

Answer 8

equals PAH clearance

Question 9

what is the equation for renal blood flow?

Answer 9

renal blood flow = renal plasma flow divided by haematocrit

Question 10

what is equation links FF to GFR and RPF

Answer 10

FF = GFR/ RPF

Question 11

what equation links FF to clearance of inulin/ creatinine (GFR) and clearance of PAH (RPF)

Answer 11

FF = Clearance of inulin or creatinine / clearance of PAH