Renal-Chapter 28 pt 2

Question 1

What is renal clearance?

Answer 1

The volume of plasma cleared of a substance per unit of time.

Question 2

Give renal clearance formula

Answer 2

Clearance of substance= urinary concentrationXurine flow rate/plasma concentration

Question 3

What would be renal clearance of substance that is freely filtered and not reabsorbed or secreted?

Answer 3

Cs=UsXV/Ps=GFR

Question 4

What is formula of urinary excretion

Answer 4

UsXV

Question 5

What is formula of filtration rate of substance by kidney

Answer 5

GFRXPs

Question 6

What substances can be used to estimate GFR

Answer 6

Creatinine clearance

Plasma creatinine concentration

Insulin clearance

Question 7

What makes creatinine clearance not a perfect marker of GFR

Answer 7

Small amts secreted by tubules

Slight error in measuring plasma creatinine

(but these two errors normally cancel each other out

Question 8

Formula when creatinine clearance used to calculate GFR

Answer 8

Ccr=UcrXV/Pcr=GFR

Question 9

What are nomral canine creatinine plasma concentration values

Answer 9

0.6-1.4 mg/dl

Question 10

When plasma concentration is 2X the normal, what happends to GFR?

Answer 10

GFR is reduced to 50%

Question 11

If a substance were copletely cleared on a pass through the kidney, clearance would equal

Answer 11

Clearance=RPF

Question 12

What is used to estimate RPF?

Answer 12

Para-aminohippuric acid (PAH)