Renal Cancer Flashcards
What are the 2 forms?
Wilm’s tumor and renal cell carcinoma
Wilm’s tumor?
- composed of embryonic tissue
- mostly impacts 1 kidney
- 2 -5 yr olds mainly
- composed of fetal tissue
Etiology of Wilm’s tumor?
- associated with congenital abnormalities (when a child has this malignancy, they perhaps have other congenital defects)
- associated with chromosome abnormalities
(WT1 on chromosome 11) - single mass
WT1?
wilm’s tumor gene located on chromosome 11 -> this protein (wilm’s tumor) codes for a protein involved in kidney development. If this gene is defected, you will have a problem with this development.
Explain the stages
stage 1 - within the kidney (not affecting the capsule, when you go in surgically, you remove the malignant part and nothing else)
stage 2 - into the capsule (it has not invaded/ extended into the capsule. when you go in surgically, you have to excise the damaged part of the capsule too)
stage 3 - entered the abdomen
stage 4 - lung mets
What does Wilm’s tumor present as?
a Mass (palpable) and HTN as a complication (EDEMA)
diagnostics for renal cancer?
- US
- CT
Treatment for Wilm’s tumor?
- surgery and chemo usually
- good prognosis (70-90% survival rate)
Who does renal cell carcinoma occur in?
Prevalence is 2x higher in men oppose to women 2:1
Age of onset of renal cell carcinoma?
> 50 yrs (mean age = 60)
Where does renal cell carcinoma occur?
mostly in upper pole of kidney
Risks for renal cell carcinoma ?
Smoking, HTN, Obesity, Polycystic Kidney Disease
Renal cell carcinoma?
- 4 cellular forms with different genetics
- largely silent
What is 1 form of renal cell carcinoma?
Clear cell carcinoma
Clear cell carcinoma?
(70-80%) deletion on chromosome 3. Proximal tubular epithelial cells
