Glomerular Disease

Question 1

Glomerulus?

Answer 1

Capillary network that sits in the Bowmans capsule

Question 2

2 main functions of the glomerulus?

Answer 2

Ultrafiltration and reabsorption

Question 3

What occurs if you have increased permeability?

Answer 3

increased urine ouput; more components filtered out

Question 4

What occurs if you have decreased permeability?

Answer 4

decreased urine output; fluid retention

Question 5

List the 5 categories that the glomerular disease is divided into.

Answer 5

1. Acute nephritic syndrome
2. Nephrotic syndrome
3. asymptomatic proteinuria and hematuria
4. acute glomerulonephritis
5. chronic glomerulonenephritis

Question 6

Acute nephritic syndrome?

Answer 6

Decrease in GFR -> retain fluids (H2O and electrolytes) & nitrogenous wastes
- results in very serious complications: azotemia, HTN, edema

Question 7

Nephrotic syndromes?

Answer 7

• Increased GFR -> lose components in the urine that should not be excreted (proteins, cells)
• Proteinuria, hypoalbuminemia (deficiency of albumin, which is protein lost in the urine)
• Hyperlipidemia r/t liver responding to hypoalbuminemia by producing more proteins, and at the same time producing more LDLs as well -> lipiduria

Question 8

Asymptomatic Proteinuria and Hematuria?

Answer 8

asymptomatic in terms of obvious renal damage -> no impairment of kidney function (GFR is normal). Far less proteinuria than seen in nephrotic syndromes (less severe)

Question 9

Which type of hypersensitivity occurs in glomerular disease.

Answer 9

type 3 hypersensitivity