Renal Basics Flashcards
Functions of the kidney
- Filtration= clearance
- Blood pressure
- Na+ homeostasis
- H2O homeostasis
- K+ homeostasis
- Bone & mineral homeostasis
- Acid/base homeostasis
- RBC production & regulation
- Gluconeogenesis
Functions of the kidney
- Filtration= clearance
- Blood pressure
- Na+ homeostasis
- H2O homeostasis
- K+ homeostasis
- Bone & mineral homeostasis
- Acid/base homeostasis
- RBC production & regulation
- Gluconeogenesis
Components of the filtration barrier
Capillary endothelium
Basement membrane
Podocytes
Renal Plasma Flow
The amount of plasma (non-cellular) that flows into the kidney- 60% or 600 ml/min; the other 40% is blood made up of RBC’s
Glomerulus filters via 2 primary mechanisms
- Size:
a. Capillary endothelium
b. basement membrane
c. podocytes - Charge: cationic better than anionic
Size- freely filtered
Size- excluded
> 70,000 D
Albumin is 66,000 D
GFR
the movement of fluid and solute across from the capillary lumen into Bowman’s space across ALL glomeruli in BOTH kidneys
GFR equation
Kf(Pgc+ pibs) - (Pbs+ pigc)
P gc= hydrostatic pressure in glomerular cap
P bs= “ “ in bowman’s space
Pi bs= Osmotic pressure in bowman’s space
Pi gc
Components of the filtration barrier
??? I don’t know
Renal Plasma Flow
The amount of plasma (non-cellular) that flows into the kidney- 60% or 600 ml/min; the other 40% is blood made up of RBC’s
Glomerulus filters via 2 primary mechanisms
- Size:
a. Capillary endothelium
b. basement membrane
c. podocytes - Charge: cationic better than anionic
Size- freely filtered
Size- excluded
> 70,000 D
Albumin is 66,000 D
GFR
the movement of fluid & solute across from the capillary lumen into Bowman’s space across ALL glomeruli in BOTH kidneys
