renal and urologic structure Flashcards
upper urinary system
kidneys (form urine)
ureters (drains urine)
lower urinary system
bladder (stores urine)
urethra (outflow of urine)
kidneys
adrenal gland on top of each
hilus on medial side
nephron
cortex and medulla (loop of Henle and collecting tubules)
main functional unit of the kidneys
nephron function
tubular reabsorption, secretion, transport, and excretion
primary function = filtration
ADH
secreted by the posterior pituitary
increase water permeability + reabsorption
decrease urine output
Aldosterone
adrenal cortex
epithelia cells int he distal tubule + collecting duct to reabsorb sodium + excrete potassium
Kidney function: regulate volume + make of ECF
glomerular: blood filtered by hydrostatic pressure
normal >90
tubular: reabsorption (tubules to capillaries); secretion (capillaries to tubules)
secrete H+
Kidney function: excrete waste
filtration, reabsorption, secretion
form urine (glomerulus filtration, tubular reabsorption and secretion)
Kidney function: control BP and RBC production
renin-angiotensin-aldosterone
RBC: erythropoietin
decrease renal blood flow
Activate Vit D
convert form food/sun to active form that body needs
Acid-base balance
bicarbonate reabsorb
H+ secreted
Blood Urea Nitrogen (BUN)
normal 10-20 mg/dL
Creatinine (Cr)
normal 0.5-1.2 mg/dL
Glomerular filtration rate (GFR)
normal >90
changes with age
decrease when older
Renal/urologic concerns: urinary tract obstruction
interference with the flow of urine (stones)
severity by location and duration
Hydroureter
much urine in ureter
Hydronephrosis
enlarge renal pelvis
ureterohydronephrosis
dilation of renal pelvis + ureter
Renal/urologic concerns: renal insufficiency (lower)
altered storing and emptying
neurogenic bladder (spinal cord)
obstruction (tumor/prostate)
acute renal failure
rapid decline in GFR
alteration in secretion or reabsorption
elevated BUN, CR, oliguria (urine output <30 ml/h or <400 ml/day)
Pre-renal
most common
Intrarenal acute renal failure
acute tubular necrosis is the most common cause
postrenal ARF
with UTO that effects both kidneys
initiation phase
oliguric <30 ml/h, <400 ml/day for 1-3 weeks
increase BUN + Cr
Maintenance phase
diuresis-damage nephron
increase urine output
>600 ml/day
Recovery phase
3-12 months
function returns
BUN+Cr return to WNL
Acute Renal Failure Reasons
drug toxicity (antibiotics, NSAID)
hemodynamic: shock, liver failure; infection
Chronic Renal Failure Reasons
diabetes, hypertension, chronic glomerulonephritis, atherosclerosis
Chronic Renal Failure
irreversible loss of renal function that effects nearly all organ systems
Anatomical changes (age)
70s: 50% loss of functioning glomeruli
Physical changes (age)
decrease renal blood flow
decrease GFR, CrCl
Increase BUN + Cr
decrease ability to concentrate urine
altered excretion of water, NA, K, acid