Renal anatomy Flashcards
osmotic diuretic that increases tubular fluid osmolarity in the PCT –> increased urine flow
Mannitol
what in the basolateral membrane extrudes Na from renal tubular cells into the interstitium?
Na/K ATPase
a sodium-phosphate cotransporter which serves as the primary functional regulator of phosphate reabsorption.
NPT2
induces NPT2 endocytosis → ↓ reabsorption of phosphate and ↓ reabsorption of HCO3-
Parathyroid hormone
PTH induces endocytosis of what?
NPT2
Reabsorption of filtered HCO3- is directly coupled to renal H secretion via the action of carbonic anhydrase and XXXX.
Na/H+ antiporter
synthesized from glutamine within the cells lining the PCT
Ammonia (NH3)
Fraction of filtered Na+ and H2O reabsorption in PCT
~67%
diuretics that act in the PCT by inhibiting the reabsorption of filtered HCO3-.
Carbonic anhydrase inhibitors (eg, acetazolamide)
Where do carbonic anhydrase inhibitors (eg, acetazolamide) work?
PCT
Important transporter in the thick ascending limb of Henle’s loop
Na-K-2Cl cotransporter
3 loop diuretics
furosemide, bumetanide, ethacrynic acid
block the NKCC (Na/K/2Cl-) symporter in the TAL (thick ascending limb) of Henle’s loop
Loop diuretics
allow electrochemical potential gradient to drive further reabsorption of cations: K, Mg+ and Ca+
K leak channels in the luminal membrane
the renal artery emerges from the descending aorta at the level of
L2 (second lumbar vertebra).
Vascular supply of bladder
internal iliac
cells in collecting tubules
principal and intercalated cells
actions of principal cells in collecting tubules
reabsorb Na and H2O; secrete K+
site of action for K sparing diuretics
principal cells
