Renal -AKI Flashcards
Most common cause of aki
Pre renal(55%)
Most common renal cause of aki
Tubulointerstitial disease (90%)
New markers of ATIN
Osteopontin
Ngal neutrophil gelatinase ass lipocalin
Il 18
Kidney injury molecule
Criterias for AKI
RIFLE
AKIN
KDIGO
KD -IGO STAGES
Q a pt has creatinine 2 times the baseline and urine output less than 0.5ml/kg/hr for more than 12 hrs
Which stage is he in
1
2
3
Second stage
Site of tubular injury in atin
S3 segment of PTA > ThAL
Causes of renal cortical necrosis which lead to ckd
Acute pancreatitis
Abruptio placentae
Snake bite
Most common pre renal cause of AKI
Sepsis Post op sepsis Complicated uti Cirrhosis Diabetes foot Tropical infection -lepto ans scrub typhus
Three phase of atin
Tubular injury phase 1
Tubuloglomerular feedback phase 2
Recovery phase 3
What happens in phase 1
Na K Ca P Mg levels low
Urine output increased
Why is there low urine output in phase 2
Because of increased urine excretion
Tubuloglomerular feedback is activated leading to decrease gfr
Complications occurring in phase 2
Hypervolemia leads to volume overload increased potassium in serum arrythmia
Metabolic acidosis uremia
Complications of atin
Uremia
Hypovolemia hypervolemia
Hyponatremia
Hyperkalemia
A pt has non specific hyaline cast in urine Osmolality 800-900 Sp gravity 1.020-1.040 Fena less than 1 Aki?
Prerenal aki
Urine sodium less than 20 mcg/l
Urine /plasma creatinine more than 40
Cast seen in ischemia atin
Wbc cast
Eosinophilic
Muddy brown epithelial cast
Best parameter for Differentiating prerenal and ischemia atin
Fena
Normal 1-2
Dose dependant tubular injury causes
VACE
Vancomycin
Aminoglycoside (pct)amphotericin b (dct)
Cisplatin cyclophosphamide
Ethylene glycol
Drug independent tubular injury type 4 HSN
BRAND PPI
B lactam Rifampicin Allopurinol Nsaid Diuretic
Dose dependant intratubular obstruction
MITAS
Methotrexate
Indinavir. Triamterene
Acyclovir
Sulfonamide
Most common mechanisn of nsaid induced kidney disease
Blocking of pg induced afferent arterioles vasodilation (pre renal aki)
Features of nsaid induced kidney disease
Fena less than 1
Oliguria
Hyperkalemia
What is analgesic nephropathy
Its features
Phenacetin aspirin caffeine
Medullary hypoxia
Calcification
Contrast induced aki caused by
It can be prevented by
High volume high osmolar ionic contrast
Prevention.
Low volume low osmolar non ionic contrast like hexol
Fluids 1ml/kg/hr giver 6hrs before and 12-24 hr after procedure
If egfr less than 30 ml/min, mri contrast gadolinum should he avoided why
Nephrogenic systemic fibrosis