Renal -AKI Flashcards
Most common cause of aki
Pre renal(55%)
Most common renal cause of aki
Tubulointerstitial disease (90%)
New markers of ATIN
Osteopontin
Ngal neutrophil gelatinase ass lipocalin
Il 18
Kidney injury molecule
Criterias for AKI
RIFLE
AKIN
KDIGO
KD -IGO STAGES
Q a pt has creatinine 2 times the baseline and urine output less than 0.5ml/kg/hr for more than 12 hrs
Which stage is he in
1
2
3
Second stage
Site of tubular injury in atin
S3 segment of PTA > ThAL
Causes of renal cortical necrosis which lead to ckd
Acute pancreatitis
Abruptio placentae
Snake bite
Most common pre renal cause of AKI
Sepsis Post op sepsis Complicated uti Cirrhosis Diabetes foot Tropical infection -lepto ans scrub typhus
Three phase of atin
Tubular injury phase 1
Tubuloglomerular feedback phase 2
Recovery phase 3
What happens in phase 1
Na K Ca P Mg levels low
Urine output increased
Why is there low urine output in phase 2
Because of increased urine excretion
Tubuloglomerular feedback is activated leading to decrease gfr
Complications occurring in phase 2
Hypervolemia leads to volume overload increased potassium in serum arrythmia
Metabolic acidosis uremia
Complications of atin
Uremia
Hypovolemia hypervolemia
Hyponatremia
Hyperkalemia
A pt has non specific hyaline cast in urine Osmolality 800-900 Sp gravity 1.020-1.040 Fena less than 1 Aki?
Prerenal aki
Urine sodium less than 20 mcg/l
Urine /plasma creatinine more than 40
Cast seen in ischemia atin
Wbc cast
Eosinophilic
Muddy brown epithelial cast
Best parameter for Differentiating prerenal and ischemia atin
Fena
Normal 1-2