Anatomy And Physiology Of Kidney Flashcards
Urogenital system develops from
Intermediate mesoderm which develops into Gonads Paramesonephric duct Mesonephric duct Nephrogenic cord (urogenital ridge)
Excretory and collecting part of urogenital system develops from
Excretory- nephrogenic cord (metanephric blastema)
Collecting- mesonephric duct by 5th week
Epithelial mesenchymal interaction occurs when
First fully formed nephron when
Urine formation
6-8th week
End of 8th week
9-10th week
WT1 mutation leads to
WT1 is on chromosome
WAGR SYNDROME Wilms Aniridia Genitourinary anomaly Retardation
Chromosome 11p
Denys Drash Syndrome is due to
Wilms
Early onset renal failure
Male pseudo hermaphroditism
Beckwith wiedemann syndrome occurs due to mutation of
Clinical feature
WT2 gene
Organomegaly
Macroglossia
Hemihypertrophy
Omphalocele
RET/GDNF MUTATION gives rise to
Bilateral renal agenesis
Potter’s syndrome
B/L renal agenesis
Pulmonary hypoplasia
Disc shaped adrenal gland
U/L renal agenesis in females is due to mutation of
Clinical feature
PAX2 mutation
Risk of HTN
optic nerve coloboma
Ascent of kidney with rotation occurs during
9-10 th week IUL
Relation of birth weight and gfr
If birth weight is 2 kg nephron 2.5 lac
If BW 3kg nephron 9 lac
Causes of renal papillary necrosis
DM with complicated UTI M. C.
SNAKE BITE
SICKLE CELL ANEMIA
ANALGESIC NEPHROPATHY
Uncomplicated UTI IS?
when healthy young sexually active female develops cystitis
In a 6yr old boy with wbc in urine and culture positive for e coli
Diagnosis is
Investigation done further
Diagnosis complicated uti Inv USG abdomen -CAKUT anomaly MCU/VCU DMSA -LOOK FOR SCARRING Dimethyl mercaptosuccinic acid
Which Renal artery is longer?
Which renal vein is longer
Right renal artery
Left renal vein
