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PPS 2018 > Renal > Flashcards

Renal Flashcards

1
Q

Most common chronic glomerular disease
Focal segmental mesangial proliferation
Gross hematuria 1-2 days after URTI or GI infection
Normal serum C3

A

IgA nephropathy (Berger nephropathy)

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2
Q

Caused by mutations inthe genes coding for type IV collagen
Foam cells
Hematuria 1-2 days after URTI
Anterior lenticonus is pathognomonic
Macular flecks, recurrent corneal ulcerations, GBM thicking and thinning, sensorineural deafness

A

Alport syndrome

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3
Q

Microscopic hematuria and isolated thinning of the GBM on EM

A

Thin basement membrane disease

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4
Q

“Lumpy bumpy” deposits of Ig and complement on GBM and mesangium
Depressed C3

A

Acute poststreptococcal GN

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5
Q

Hematuria in AGN develops __ after an antecedent streptococcal pharyngitis and __ after a streptococcal pyoderma

A

1-2 weeks after pharyngitis

3-6 weeks after pyoderma

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6
Q

The best antibody titer to document cutaneous streptococcal infection

A

anti-DNAse B level

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7
Q

Most common cause of membranous glomerulopathy worldwide

A

Malaria

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8
Q

Spikelike pattern of granular deposits of IgG and C3 on the epithelial side of the GBM
Thickening of the GBM
Manifests as nephrotic syndrome

A

Membranous glomerulopathy

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9
Q

Treatment of membranous glomerulopathy

A

Immunosuppressive therapy with an extended course of prednisone

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10
Q

Lobar pattern of diffuse mesangial expansion, endocapillary proliferatin, increase in mesangial cells and matrix
Glomerular capillary walls are thickened

A

Type I MPGN (most common)

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11
Q

Dense deposit disease
Not mediated by immune complex
Severely depressed complement levels
C3 nephritic factor is present in many patients

A

Type 2 MPGN

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12
Q

Pulmonary hemorrhage and glomerulonephritis
Antibodies directed against specific epitopes of type IV collagen
Continuous linear deposition of IgG along the GBM
C3 is normal, (+) anti-GBM antibody

A

Good pasture disease

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13
Q

Microangiopathic hemolytic anemia, thrombocytopenia, renal insufficiency. Diagnosis?

A

Hemolytic uremic syndrome

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14
Q

Definition of nephrotic range proteinuria

A

> 40 mg/m2/hr

or first morning protein:crea of >2-3:1

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15
Q

Nephrotic syndrome patient who continues to have proteinuria of 2+ or greater after 8 weeks of steroid therapy

A

steroid resistant

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16
Q

Nephrotic syndrome patient who relapses while on alternate-day steroid therapy or within 28 days of completing a successful course of prednisone

A

Steroid dependent

17
Q

Nephrotic syndrome patient who responds well to prednisone therapy but relapses at least 4 times in a 12-month period

A

Frequent relapser

18
Q

Cumulative threshold dose of cyclophosphamide above which oligo- or azoospermia occurs in boys is __

A

> 250 mg/kg

19
Q

Most common organism causing spontaneous bacterial peritonitis

A

streptococcus pneumoniae

20
Q

Vaccines can be administered after corticosteroid therapy has been discontinued for how long?

A

1 month

21
Q 
USG >1.020
UOsm >500 mOsm/kg
UNa <20 mEq/L
FENa <1% (<2.5% in neonates)
Prerenal, intrinsic renal or postrenal?
A

Prerenal

22
Q 
USG <1.010
UOsm <350 mOsm/kg
UNa >40 mEq/L
FENa >2% (>10% in neonates)
Prerenal, intrinsic renal or postrenal?
A

Intrinsic renal

23
Q

Vitamin D for renal osteodystrophy in patients with low 25-D levels

A

ergocalciferol

24
Q

Vitamin D for renal osteodystrophy in patients with normal 25-D level but elevated PTH

A

calcitriol

25
Q

In girls, first UTI occurs by the age of __

A

5 yr

26
Q

In boys, first UTI occurs by the age of __

A

1 yr

27
Q

In girls, 75-90% of UTIs are caused by these 3 pathogens

A

E. coli
Klebsiella
Proteus

28
Q

If the testis has not descended by __, it will remain undescended

A

4 mo

29
Q

The congenital undescended testis should be treated surgically not later than __

A

9-15 mo

PPS 2018 (17 decks)

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