renal 4 Flashcards
metabolism produces
h ions
gain H; lose H
kidney ;urine
buffer for H
bicarb
resp acidosis
accum of CO2 which makes H
any problem with ventilation
inc CO2
diabetics and hypoxia
produce acid
normal diet
make diet
net exogenous acid production
acid made from protein digestion and diabetes and hypoxia
tf amt of acid in body is less than ingest per day
true
tf most of bicarb reabsorption occurs in prox tubule an none goes into urine
t
tf bicarb is reabsorbed at all parts of renal tubule
t
at the prox tubule — bicarb is reabs and — h+ is secreter
1;1
prox tubule luminal mebrane how do you get H+ out into lumen
thru exchanger(with NA) and pumP

how does HCO3 get to cap at basolat membrane of Prox tubule
cotransport with NA
exchange with Cl

tf in prox tubule and collecting duct
h secreted and HCO3 reabsorbed
t
and both 1;1
at luminal side of the collecting duct
H get secreted by
pump with H+
and exchange with K(need ATP)

how does hco3 get to cap side in CD
exchange with CL

intercalated alpha type cell occurs
at CD to resorb bicarb
principal cells have wat features
aqp2 and Na channel
located in CD
interacalated cells
H pump
beta intercalated types cells are used to
transfer hco3 to tube in alkalosis(excess hco3 in blood)
purpose of interacalated alpha; vs beta cells
reabsorb bicarc; secrete bicarb
in intercalated beta cells of the cd
hco3 secreted in eaxchanged for
- CL

reabs H+ and secretion of Bicarb occurs in
interacalate alpha
intercalated beta
prox tubule
intercalated beta
