Regulation of Enzyme Activity Flashcards
1
Q
What are different ways that the activity of key enzymes in metabolic pathways regulated?
A
covalent modification
proteolytic cleavage
association with other polypeptides
allosteric regulation
2
Q
What is allosteric regulation?
A
modification of active site activity through interactions of molecules with other specific sites on the enzyme (allosteric sites)
3
Q
What are the types of feedback regulation?
A
negative feedback (feedback inhibition)
positive feedback (feedback stimulation)
feedforward stimulation
4
Q
What is feedback inhibtion?
A
when an end-product will shut off an enzyme early in the pathway
5
Q
What is feedforward stimulation?
A
stimulation of an enzyme by its substrate or by a molecule used in the synthesis of the substrate
