Regenerative Vision

Question 1

What is RPE responsible for

Answer 1

absorbs scattered light and is also protective by absorbing harmful rays.

Question 2

What are two types of visual loss

Answer 2

1. Central vision loss

2. Peripheral field loss

Question 3

What are the types of central vision loss

Answer 3

1. macular dysfunction
2. AMD
3. diabetic retinopathy
4. Stargardts disease

Question 4

What are types of peripheral field loss

Answer 4

1. Glaucoma

2. RP

Question 5

What are types of AMD?

Answer 5

1. Drusen
2. Drusen & AMD
3. Atrophic AMD
4. Exudative AMD

Question 6

Describe hard vs soft drusen

Answer 6

Hard: small well defined spots, usually innocuous
Soft: larger, ill defined spots that can enlarge and coalesce. Inc risk of AMD

Question 7

What is choroidal neovascularization

Answer 7

Serious form of AMD, you get rapid vision loss, sub retinal lesions and blood hemorrhages observed

Question 8

Stargardts looks like the ____ type of AMD. You see drusen deposits around the macula and they are much more easily to observe. You cannot stop the progression of stargardt’s disease

Answer 8

dry

Question 9

RP should be regarded as a ____ description of sev related, yet distinct, dystrophies of the PR’s and the pigment epithelium. The PR’s that are affected may be rods or cones, and the RPE may be affected centrally or peripherally.

Answer 9

phenotypic

Question 10

The rate of RP is ______ patients. Within the class of RPE there are ___ genetic defects.

Answer 10

1/4000; 70

Question 11

What are symptoms of RP

Answer 11

1. Nyctalopia (loss of night vision)

2. Tunnel vision (loss of peripheral vision)

Question 12

How does the stem cell regeneration theory work

Answer 12

1. Start with embryonic/adult stem cell.
2. Culture them with growth factors that turn into retinal progenitor cells.
3. Become RP cells
4. Implant them in eye

Question 13

What is stem cell replacement dependent on

Answer 13

1. Concentration
2. Combination
3. Location
4. Function

Question 14

In regards to stem cell replacement, where is it where we have the biggest struggle

Answer 14

Function; when body is developing, the cells are getting signals telling them where to go and who to connect with. You have to turn on other factors and teach cells how to work and function properly.

Question 15

Most stem cell research is targeted at treating ____ or diabetic retinopathy.

Answer 15

AMD;