REGAL Antivirals Flashcards
HSV, VZV Tx
Acyclovir, Valacyclovir
Penciclovir, Famciclovir
Trifluridine, Cidofovir
Foscarnet
CMV Tx
Ganciclovir, Valganciclovir
HBV Tx
Lamivudine
Tenofovir
Entecavir
Adefovir
HCV Tx
Peg INF-α
Ribavirin
Respiratory Syncytial Virus Tx
Ribavirin
Influenza Tx
Zanamivir, Oseltamivir
Papillomavirus Tx
Imiquimod
Acyclovir, Valacyclovir: Class, MOA, TU
Class: Purine Analog
MOA: Phosphorylated by virus specific enzymes -> inhibit DNA synth
TU: Herpes
Penciclovir, Famciclovir: Class, MOA, TU
Class: Purine Analog
MOA: phosphorylated by virus specific enzymes -> inhibit DNA synth
TU: Herpes
Ganciclovir, Valganciclovir: Class, MOA, TU
Class: Purine Analog
MOA: phosphorylated by virus specific enzymes -> inhibit DNA synth
TU: CMV
Ganciclovir Toxicity?
Bone Marrow Suppression
Trifluridine: Class, MOA
Class: Pyrimidine analog
MOA: phosphorylated by host enzymes -> inhibit DNA synth
Foscarnet: Class, MOA
Class: Pyrophosphate analog
MOA: Inhibits DNA Pol non-competitively
Lamivudine: Class, MOA, TU
Class: NRTI
MOA: Reverse Transcriptase incorporates Lamivudine into chain -> chain termination
TU: HBV, HIV
Tenofovir: Class, MOA, TU
Class: NRTI
MOA: Reverse Transcriptase incorporates Tenofovir into chain -> chain termination
TU: HBV, HIV
Entecavir: Class, TU
Class: NRTI
TU: HBV
Abefovir: Class, TU
Class: NRTI
TU: HBV
Zanamivir, Oseltamivir: Class, MOA, TU
Class: Neuraminidase inhibitors
MOA: Block neuraminidase (viral protein) -> ↓release of virus from infected cell
TU: Influenza
Ribavirin: MOA, TU
MOA: Inhibits viral replication
TU: HCV, RSV
Imiquimod: Class, TU
Class: Immune System Stimulant
TU: Papillomavirus
