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Erik's IHO Week 5 > REGAL Antivirals > Flashcards

REGAL Antivirals Flashcards

1
Q

HSV, VZV Tx

A

Acyclovir, Valacyclovir
Penciclovir, Famciclovir

Trifluridine, Cidofovir

Foscarnet

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2
Q

CMV Tx

A

Ganciclovir, Valganciclovir

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3
Q

HBV Tx

A

Lamivudine
Tenofovir
Entecavir
Adefovir

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4
Q

HCV Tx

A

Peg INF-α

Ribavirin

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5
Q

Respiratory Syncytial Virus Tx

A

Ribavirin

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6
Q

Influenza Tx

A

Zanamivir, Oseltamivir

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7
Q

Papillomavirus Tx

A

Imiquimod

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8
Q

Acyclovir, Valacyclovir: Class, MOA, TU

A

Class: Purine Analog
MOA: Phosphorylated by virus specific enzymes -> inhibit DNA synth
TU: Herpes

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9
Q

Penciclovir, Famciclovir: Class, MOA, TU

A

Class: Purine Analog
MOA: phosphorylated by virus specific enzymes -> inhibit DNA synth
TU: Herpes

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10
Q

Ganciclovir, Valganciclovir: Class, MOA, TU

A

Class: Purine Analog
MOA: phosphorylated by virus specific enzymes -> inhibit DNA synth
TU: CMV

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11
Q

Ganciclovir Toxicity?

A

Bone Marrow Suppression

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12
Q

Trifluridine: Class, MOA

A

Class: Pyrimidine analog
MOA: phosphorylated by host enzymes -> inhibit DNA synth

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13
Q

Foscarnet: Class, MOA

A

Class: Pyrophosphate analog
MOA: Inhibits DNA Pol non-competitively

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14
Q

Lamivudine: Class, MOA, TU

A

Class: NRTI
MOA: Reverse Transcriptase incorporates Lamivudine into chain -> chain termination
TU: HBV, HIV

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15
Q

Tenofovir: Class, MOA, TU

A

Class: NRTI
MOA: Reverse Transcriptase incorporates Tenofovir into chain -> chain termination
TU: HBV, HIV

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16
Q

Entecavir: Class, TU

A

Class: NRTI
TU: HBV

17
Q

Abefovir: Class, TU

A

Class: NRTI
TU: HBV

18
Q

Zanamivir, Oseltamivir: Class, MOA, TU

A

Class: Neuraminidase inhibitors
MOA: Block neuraminidase (viral protein) -> ↓release of virus from infected cell
TU: Influenza

19
Q

Ribavirin: MOA, TU

A

MOA: Inhibits viral replication
TU: HCV, RSV

20
Q

Imiquimod: Class, TU

A

Class: Immune System Stimulant
TU: Papillomavirus

Erik's IHO Week 5 (7 decks)

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