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Hematology > Reference Value > Flashcards

Reference Value Flashcards

1
Q

RBC COUNT values

A 
Newborn- 4.1-6.1 mill/mm3
Children- 3.6-5.5 mill/mm3
Males- 4.6-6.0 mill/mm3
Females-4.2-5.0
Pregnancy- slightly lower
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2
Q

Haemoglobin reference range

A

Male-13.3-16.2g/dL

Females- 12-15.8 g/dL

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3
Q

Pcv is also called -&-

A

Hematocrit & EVF( erythrocyte volume fraction)

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4
Q

Hematocrit reference range

A

Male - 40-50%

Female- 36-46%

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5
Q

MCV( mean corpuscular volume) definition
Formula
values

A

Average volume of RBC
Mathematically- hematocrit/RBC count * 100
Value- 79-97fL

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6
Q

Mean corpuscular haemoglobin.
Definition
Formula
Reference range

A

Amount of haemoglobin in a single RBC
MCH- haemoglobin conc /RBC count * 100
29.5pg+-2.5

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7
Q

Mean corpuscular haemoglobin conc(MCHC)
Definition
Formula
Values

A

Average haemoglobin concentration per unit volume(100ml) of PCV

Formula- Haemoglobin/hematocrit * 100

32-36g/dL of RBC

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8
Q

Function of MCHC

A

Correlates haemoglobin content with Red cell volume

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9
Q

RDW- Red cell distribution width is an expression of

A

Anisocytosis

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10
Q

RDW is a coefficient of- & reflects

A

Of variation of distribution of individual RBC volume

Size variability of RBC

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11
Q

Measuring RDW can provide insights for

A

Anemia

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12
Q

Microcytosis

A

RBC smaller than normal

MCV - less than 80fL

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13
Q

Microcytosis is associated with

A

Iron deficiency Anemia

Thalassemia

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14
Q

Marked microcytosis with normal RDW is suggestive of

A

Thalassemia

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15
Q

RDW values

A

Coefficient of variation- 12.8%+-1.2

Standard deviation of RBC RBC- 35fL-45fL

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16
Q

Reticulocyte count
Formula
Values

A

(Reticulocyte counted/1000RC Counted)*100
Newborn-2-5%
Children and adults-0.5-2.5%

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17
Q

Absolute reticulocyte count is

A

The number of reticulocyte in 1 cm3 of blood

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18
Q

Absolute reticulocyte count formula

Values Assad

A

Reticulocyte percentage*Red cell count in millions/cm3

50,000-100,000/cm3

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19
Q

Corrected reticulocyte count is important in measuring

What is the formula

A

Degree of Anaemia.

Reticulocyte count * PCV of patient / Average PCV for age

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20
Q

What is Reticulocyte production index.

Formula

Interpretation of value

A

This is the response of the bone marrow to anaemia.

Corrected reticulocyte count/ maturation time

> /=2%(>100,000ul) is an appropriate response
<2%(75,000 ) is an inappropriate response for the degree of Anaemia

21
Q

What is the relationship between the maturation time of reticulocytes and PCV

A

Inverse relationship

22
Q

Which of the ffg statement is true/false

Leucocyte count doesn’t show a wide variability from birth and throughout life

Leucocytes shows ethnic variability

Total leucocyte count is high at birth

Neutrophils predominates after the 5-7 yrs

Neutrophils level peaks at birth for a neonate >28 wks of gestation period within 6-8hrs and this is the same time for that <28wks gestation

Neutrophils count increases over the next few weeks after birth.

A 
F
T
T
T
F
F
23
Q

lymphocytes level drop in the first 3 days of birth. T/F

A

True

24
Q

Lymphocyte level peaks on the 10th day after birth then predominates(60%). t/F

A

False- only predominates within 5-7yrs

25
Q

Neutrophils predominates again after 5-7years. t/F

A

T

26
Q

Leucocyte count slightly higher in boys than girls. T/F

A

False

27
Q

After menopause women WBC count drops less than men of same age. T/F

A

T

28
Q

Some women’s leucocyte count shows a rhythm with their menstrual cycle. T/F

A

T

29
Q

Genetic factor controls the Neutrophil:Lymphocyte ratio in Africans and increases the Neutrophil count.

A

False.

30
Q

Benign ethnic neutropenia occurs where

A

In 5% Africans < 1.5 * 10^9/L

31
Q

White cell count reference range.

Slightly lower in Africans

A

4-10 * 10^9/L

2-9 * 10^9/L

32
Q

There is a slight diurnal variation in platelet count. T/F

A

T

33
Q

Europeans have a lower platelet (10-20%) than Africans. T/F

A

False

34
Q

Strenuous exercise increases thrombocytes counts by 30-40%

A

True

35
Q

Women experience increase in platelet count at menstruation

A

False

36
Q

Women experience a decrease in platelet count in first year after birth.

A

False

37
Q

Reference range for blood platelets. Africans have lesser value

A

150-400 * 10^9/L

100-300 * 10^9/L

38
Q

Haemoglobin electrophoresis percentages

A

H A1- 96.1-99
H A2- 0.8-3.4
H F - 0.0-1.2

39
Q

Prothrombin time
Definition
Reference value

A

measures the time it takes a citrated blood sample to clot after
Recalcification

10-14s

40
Q

PT measures what pathway

A

Traditionally the extrinsic pathway

41
Q

What clotting factors are involved in the PT test.

A

Factors

V, VII, II,X as well as fibrinogen

42
Q

PT is prolonged in

A

Warfarin therapy
Liver disease
DIC
Deficiency/ inhibition of factors , 5,7,2,10 and vitamin K

43
Q

International Normalized ratio is

A

PTtest/PTnormal

44
Q

Activated partial thromboplastin time measures what pathways.

Reference value- 30-40s

A

Intrinsic

45
Q

Reference range for factor VIII

A

55-145% of normal

46
Q

Reference range for factor IX

A

60%-140% of normal

47
Q

Haemophilia A is caused by? And what are the degrees of Haemophilia A

A

Deficient factor VIII

Mild- >5%
Moderate- 1-5 %
Severe- < 1%

48
Q

Haemophilia B is caused by

A

Deficient Factor IX

49
Q

Bleeding time measures.

Reference value

A

Platelet function.

2-7mins

Hematology (8 decks)

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