Red Cell Metabolism

Question 1

Role of red blood cell?

Answer 1

Oxygen carriage and delivery
Energy release
Deoxygenated promote blood flow
Immune response (free radical release)
Intra-cellular buffer
K homeostasis

Question 2

What is the rate limiting reaction in haem synthesis?

Answer 2

ALA enzyme

Question 3

Which metal inhibits the haem metabolism pathway?

Answer 3

Lead - it affects ferrochelatase and ALA dehydratase

Question 4

Where does haem synthesis occur?

Answer 4

In the mitochondria and cytoplasm

Question 5

Presentation of Porphyria?

Answer 5

Acute Neuro visceral features (with or without skin lesions)
Sun-induced urticaria or erythema
Active skin lesions: erosions and Bullae
Abdominal pain
Tachycardia

Question 6

what is EPO released in response to and from where? what does it do?

Answer 6

Erythropoetin (EPO) is released kidneys when cellular hypoxia occurs

It stimulates red blood cell production

Question 7

GCSF (granulocyte colony-stimulating factor) initiates proliferation and differentiation of which cells into granulocytes?

Answer 7

precursor myeloid cells

Question 8

How do interleukins increase WBCs?

Answer 8

IL promote differentiation of other immune cells groups (↑ WBCs)

Question 9

Which hormone acts on megakaryocytes to increase platelet count?

Answer 9

Thrombopoietin (TPO)
produced by Liver and kidneys

Question 10

Which cells should not be in circulating blood in a healthy person?

Answer 10

Lymphoblasts (live in bone marrow)

Question 11

Which cells are produced by lymphoid stem cells?

Answer 11

B cells, T cells and Natural killer cells