Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Clinical biomedicine > Red blood cells > Flashcards

Red blood cells Flashcards

Understand the structure and function of red blood cells. And be able to list some common problems

1
Q

How do red blood cells perform their metabolic activity?

A

Anaerobic glycolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Why do red blood cells need to produce ATP?

A
  • Maintain cell deformability
  • Maintain water and iron transport
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the process of red blood cell creation called?

A

Erythropoesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Where is a damaged red blood cell destroyed?

A

Inside the spleen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the globin recycled into?

A

Amino acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the Haem recycled into?

A
  • Iron
  • Billirubin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the function of Erythropoetin?

A

Regulation of red cell production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What happens to Epo production during Renal hypoxia?

A

EPO production is increased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the average lifespan of a RBC?

A

120 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does an increase in reticulocytes usually show?

A

Increases rate of RBC production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Where are red blood cells destroyed?

A

Within the Red pulp section of the spleen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How does the spleen “select” for damaged cells?

A

Tiny 3ul windows seperate the splenic cords, If the cell cannot adapt it’s shape it won’t fit and therefore will be destroyted

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is O2 bound to haem?

A

Phsically

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the normal blood pH?

A

7.35-7.45

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the normal structure of an adults Haem?

A

Alpha 2, Beta 2, with each molecule surrounding a haem group

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the observable pattern in the HB dissociation curve?

A

The first oxygen molecule is hard to add, However as more are added it become easier

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How can O2 affinity be varied?

A

2,3 DPG will bind to deoxyHB, therefore reducing it’s oxygen affinity further

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the difference between oxidation and oxygenation?

A

Oxidation: Changes charge
Oxygenation: Creates oxygen molecule association

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

When are Artificial red blood cells used?

A

Only used as a last resort for military usage

20
Q

Advantages of Artificial red blood cells?

A
  • Increased shelf life
  • Universal administration
  • No risk of disease transmission
21
Q

Disadvantages of Artificial red blood cells?

A

Creates toxic free globin bi-product

22
Q

Based off the paper from 1953, Which blood group had a more common association with cancer?

A

Group A

23
Q

What is anaemia?

A

Reduced haemoglobin in blood

24
Q

What are the clinical signs/symptoms of anaemia?

A

Shortness of breath, Juandice, weakness

25
Q

What is meant by microcytic?

A

Small RBC size

26
Q

What is meant by normocytic

A

Normal RBC size

27
Q

What is meant by macrocytic?

A

Large RBC size

28
Q

What is meant by Hypochromic?

A

Low haemoglobin concentration

29
Q

What is meant by normochromic?

A

Normal Haemoglobin concentration

30
Q

What is meant by hyperchromic?

A

High haemoglobin concentration

31
Q

What is Microcytic normochromic anaemia?

A
  • Small RBC’s
  • Normal volume of haem
32
Q

What is normocytic hypochromic anaemia?

A
  • Normal sized RBC’s
  • Reduced volume of haem
33
Q

What is meant by Normocytic, Normochromic anaemia?

A
  • Normal sized RBC’s
  • Normal volume of Haem
  • Reduced RBC count overall
34
Q

What causes Normocytic Normochromic anaemia?

A

Bleeds

35
Q

What is microcytic hypochromic anaemia?

A
  • Low RBC size
  • Low Haem volume
36
Q

What causes Microcytic hypochromic anemia?

A

Iron deficiency

37
Q

What are the symptoms of microcytic hypochromic anaemia?

A

Fatigue, headaches, tinnitus

38
Q

How is Microcytic hypochromic anaemia treated?

A

Iron supplements are provided

39
Q

What is macrocytic normochromic anaemia?

A
  • Large RBC size
  • Normal Haem volume
40
Q

What causes Macrocytic normochromic anaemia?

A

B12 or folate deficiency

41
Q

What are the symptoms of macrocytic normochromic anaemia?

A

Fatigue, Dysnopea

42
Q

How is macrocytic normochromic anaemia treated?

A

B12 suppliments

43
Q

MCV stands for…

A

Mean cell volume, and related to the size of the cell

44
Q

MCH stands for…

A

Mean cell haemoglobin, and is related to HB concentration

45
Q

MCHC stands for..

A

Mean corpuscular haemoglobin concentration, and is the cell HB concentration in relation to cell size

46
Q

What type of anemia would you get from a iron deficiency?

A

Microcytic, Hypochromic anemia

47
Q

What type of anemia would you get from bone marrow infiltration?

A

Normochromic, normocytic anaemia, just a reduced number of RBC

Clinical biomedicine (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions