Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Clinical biomedicine > Haemostasis > Flashcards

Haemostasis Flashcards

1
Q

What are the five steps of haemostasis?

A
  1. Vessel spasm
  2. Platelet plug formation
  3. Coagulation
  4. Clot retraction
  5. Clot dissolution
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How does platelet plug formation occur?

A

Adhesion betwen vWF and GP1B will adhere platelet to exposed collagen, where it will roll over a gp6 causing platelet activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What occurs within the extrinsic pathway of coagulation?

A
  • Cascade of factors activated via release of tissue factorW
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What occurs during the intrinsic pathway?

A

Platelet activation via thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What happens within the common cascade?

A

Conversion of prothrombin to thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which clotting factor will create cross bridges for fibrin?

A

Factors XIIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is created from fibrinolysis?

A
  • D-dimers are formed from the breakdown of fibrin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the potential causes for bleeding disorders?

A
  • Missing clotting factors
  • Liver disease
  • Low platelets
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the potential causes of thrombosis?

A
  • Insufficient clotting factor inhibitors
  • Inappropriate platelet activation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What causes primary haemostasis disorders?

A

Platelet plug formation issues (thrombocytopenia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What causes secondary coagulation disorders?

A

Coagulation problems

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are petechiae bruises?

A

Any bruise less than 3mm in size

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are purpura bruises?

A

Any bruise between 3mm - 1cm in size

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are ecchymose bruises?

A

Any bruise > 1cm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What type of investigations can be used for haemostatic issues

A
  • Full blood counts
  • Blood smears
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How does asparin work?

A

Inhibiting production of thromboxane A2

17
Q

What coloured vacutainer is used for a coagulation assay?

A

Blue vacutainer as the citrate only tempoerarily inhibits the calcium

18
Q

What pathway does promthrobin time measure?

A

Extrinsic pathway

19
Q

What is a normal time for a prothrombin time assay?

A

11-16 seconds

20
Q

What pathway does the Activated partial thromboplastin time assess?

A

Intrinsic pathway

21
Q

What is a normal value for activated partial thromboplastin time

A

30-40 seconds

22
Q

What pathway does the thrombonin time assess?

A

Common pathway

23
Q

What is a normal response time for the thrombonin assay?

A

15-19 seconds

24
Q
A

Clinical biomedicine (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions