Red Blood Cell and Bleeding Disorders

Question 1

REed cells develop from ___________, which are large precursor cells in the bone marrow.

Answer 1

erythroblasts

Question 2

____________, formed by developing red cells, is a tetramer composed of four different subunits, each one consisting of heme and globin.

Answer 2

hemoglobin

Question 3

Heme is a ________ ring that contains an iron atom(Fe2+).

Answer 3

porphyrin ring

Question 4

적혈구가 파괴되고 나서 분비되는 물질, 담즙에 있다가 배설물을 통해 체외로 나감,배설물의 색이 이것의 영향을 받음

Answer 4

biliverdin

Question 5

_____________: a newly formed red cell that lacks a nucleus but retains some of its organelles can be identified by special strains

Answer 5

reticulocyte(immature red blood cell), 망상적혈구

Question 6

Regulatio of HEmatopoiesis
a decreased oxyen supply stimulates ________________.

Answer 6

erthropoiesis

Question 7

___________ is defined as a reduction of the total circulating red cell mass below normal limits or a subnormal level of hemoglobin.

Answer 7

anemia

Question 8

Morphologic classification of anemia
____________ anemia: reduced hemoglobin content

Answer 8

hypochromic (저색소빈혈)

Question 9

Morphologic classification of anemia
____________ anemia= iron deficiency anemia

Answer 9

hypochromic

Question 10

Morphologic classification of anemia
____________ anemia= vitamine B12 or folic acid deficiency anemia

Answer 10

macrocytic anemia

Question 11

Normocytic-normochromic enemias의 주요 예시 5가지

Answer 11

aplastic, post-hemorrhagic, hemolytic, chronic disease, sickle cell

Question 12

___________: an inherited disorder caused by intrinsic defects in the red cell membrane skeleton that render red cells spheroid less deformable and vunlnerable to splenic sequestration and destruction.

Answer 12

Hereditary spherocytosis(HS)

Question 13

Hemolytic Disease due to red cell enzyme defects:__________(효소)
enzyme function: reduce the ability of red cells to protect themselves aginst oxidative injuries and lead to hemolysis

Answer 13

G6PD(glucose-6-phosphate dehydrogenase)

Question 14

______________ disease is a common hereditary hemoglobinopathy caused by a point mutation in beta-globin thate promotes the polymerization deoxygenated Hb, leading to red cell distortion, hemolytic anemia, microvascular obstruction, and ischemic tissue damage.

Answer 14

sickle cell

Question 15

<malaria>
another effect of sickling is that it impairs the formation of membrane knobs containing a protein made by the parasite called \_\_\_\_\_\_\_\_\_\_.
</malaria>

Answer 15

PfEMP-1

Question 16

___________ syndromes: a heterogeneous group of disorders caused by inherited mutations that decrease the synthesis of either the alpha globin or beta globin chains.

Answer 16

Thalassemia