Rectal Delivery Part 2

Question 1

How should a base be chosen for a suppository?

Answer 1

choose base with lowest solubility –> high ET

Question 2

Where is cocoa butter from?

Answer 2

cocoa bean extract

– theobroma oil (edible)

Question 3

How does molecular weight of polymers affect dissolution?

Answer 3

increased MW –> decreased dissolution

Question 4

What drugs should be used with hydrophilic polymer suppositories?

Answer 4

hydrophilic oR hydrophobic are OK

– if hydrophobic, use co-solvent with water

Question 5

How can penetration be enhanced in rectal delivery?

Answer 5

1) surfactants

2) short-term calcium chelators

Question 6

What is a calcium chelator?

Answer 6

salicylic acid

Question 7

What is the polymer in a rectal gell?

Answer 7

HPMC

Question 8

What is the pH of a rectal gel?

Answer 8

6.5 - 7.2

Question 9

What are the ingredients in a rectal gel?

Answer 9

1) propylene glycol
2) EtOH
3) H2O
4) Sodium benzoate
5) benzyl alcohol
6) benzoic acid

Question 10

How is the sol-gel T altered?

Answer 10

increased P407 –> decreased T sol-gel

Question 11

What is Poloxamer 407?

Answer 11

co-polymer in a sol-gel…polyethylene oxide & propylene oxide

Question 12

What is the effect of increased temperature of a sol-gel?

Answer 12

micellization + gelation –> viscous

Question 13

What are the considerations for a sol-gel rectally?

Answer 13

concomitant drug administration can influence sol-gel T