Recreational Drugs Flashcards
Cocaine
Cocaine ha sa stimulant effect where it affects the synaptic transmission of neurotransmitters such as seratonin , dopamine and etc.
Has the most affect on dopamine
Role or dopamine cocaine
Cocaine blocks reuptake of dopamine, attachinf to any transporter molecules on the terminal buttons.
Causing a flow of dopamine within the synapse , causing dopamine to continously attach to the post synaptic receptors.
Causing a euphoric high
Long term effects
Very few receptors stay active, with some becoming much more damaged and even dead. Quantity of dopamine decreases.
This is an explanation for tolerance as higher dosages of cocaine would be needed to produce the same effect, also an explanation for withdrawal
Heroin
Heroin is a depressant stimulant which slows down activity within the CNS
When injected intravenously, it is processed into morphine
Morphine then binds to the opiod receptors within the cerebral cortex.
Agonist
Heroin is an agonist drug as it replaces another natural biochemical
Long term affects
Down regulation, where the opiod receptors becomes desensitised to the affects of the drug requiring more to undergo an affect
Research support
When the pathway thats directlt responsible for producing levels of dopamine was damaged
Mice then failed to intake heroin intravenously
But this was not the case when other parts of the brain was damaged
Shows a direct link between dopamine levels and heroin usage
Negative of research support
Human brains are much more complex than a rat brain so it wouldn’t make sense to compare.
+ animal cruelty