Receptors and Drugs

Question 1

How do drugs work?

Answer 1

They bind onto receptors on cells and produces a response

Question 2

What is the lock and key mechanism?

Answer 2

A drug will only bind to a specific target receptor

Question 3

What is an agonist drug?

Answer 3

They bind to a receptor and produces a response.

they usually mimic natural chemicals

Question 4

What is an antagonist drug?

Answer 4

it binds to a receptor and prevent other chemicals (an agonist) binding to that receptor

Question 5

What happens when a drug binds to a receptor?

Answer 5

it causes the activation of the 2nd messenger and this causes a cascade of enzyme mediated reactions to happen causing a response

Question 6

What does G protein activate when an agonist binds to the the receptor?

Answer 6

It cause adenylate cyclase enzyme to convert ATP to cAMP which causes activation of protein 1 to be activated which converts protein 2 to protein 2-p which causes decrease of calcium in smooth muscle> relaxation

Question 7

What is the second messenger in the relaxation of smooth muscle?

Answer 7

cAMP

Question 8

What are the cellular responses to drugs?

Answer 8

1. contraction
2. secretion
3. excitation
4. inhibition
5. interupption of cell cycle

Question 9

What is potency?

Answer 9

It is how much of drug is required to produce a response in a particular patient?