Receptors

Question 1

Monoamine neurotransmitters

Answer 1

• dopamine
• norepinephrine
• epinephrine
• serotonin
• acetylcholine
• antihistamine

Question 2

Amino acids

Answer 2

• GABA
• Glycine
• Glutamate

Question 3

Peptides

Answer 3

• endorphins
• cholecystokinin
• neurotensin
• neuropeptide Y
• Leptin
• Ghrelin

Question 4

Ligand gated channels

Answer 4

• ionotropic
• binding of chemical messenger alters the probability of opening of transmembrane pores or channels
• fast responses
• GABA A benzodiazepines

Question 5

Metabotropic channels

Answer 5

• those in which the receptor proteins are coupled to intracellular G proteins to open them
• slower response
• most antipsychotics, antidepressants
• influence protein synthesis and produce longer lasting effects
• DA receptors, most 5HT receptors (apart from 3) , NEN and neuropeptides including opioid

Question 6

Inhibitory neurotransmitters

Answer 6

-lead to entry of Cl-

Question 7

Excitatory neurotransmitters

Answer 7

-lead to entry of Ca2+

Question 8

Ionotropic receptors

Answer 8

• GABA A
• NMDA
• 5HT3 subtype of serotonin receptions

Question 9

G-protein coupled metabotropic receptors

Answer 9

• proteins that span the cell membrane seven times (serpentine receptors)
• act via cyclase mediated second messenger activation (GTP, ATP)
• Gs proteins are stimulatory
• Gi proteins inhibit the adenylate cyclase
• Some G protein coupled receptors act bia phospholipase C

Question 10

Glucocorticoid receptors

Answer 10

• nuclear receptor
• has cysteine rich DNA binding domain, a ligand domain and a variable amino terminal
• appon appropriate ligand binding, the nuclear receptor necomes a transcription factor and binds to DNA via zinc fingers
• located mainly in the cytoplasm but migrates to the nucleus as so as it binds its ligand

Question 11

Nuclear receptors

Answer 11

• progesterone
• androgen
• vitamin D
• eostrogen- actually in the nucleus
• T3 actually in the nucleus