Other neurotransmitters

Question 1

Glycine

Answer 1

• primary inhibitory neurotransmitter in the spinal cord
• made from serine by serine transhydroxymethylase and glycerate dehydrogenase
• acts as a mandatory adjunctive neurotransmitter for glutamate receptor
• the excitatory sites on the NMDA receptor is called non-strychnine-sensitive glycine receptor
• strychnine-sensitive glycine receptor is an inhibitory receptor seen in the spinal cord where glycine acts independently
• facilitating glycine transmission can help reduce negative symptoms of schizophrenia

Question 2

Endocannabinoids

Answer 2

• Anandamide (a weak ligand) and 2-arachnidonylglycerol (strong ligand) are both endogenous canniboids
• formed from arachidonic acid and ethanolamine
• 2 types of cannabinoid receptors- centrl (CB1) and peripheral (CB2)- both bind to THC
• anandamide lowers intraoccular pressure , decreases activity level and relieves pain

Question 3

Nerve growth factor

Answer 3

-neurotrophin

Question 4

Brain derived Nerve growth factor (BNGF)

Answer 4

• may have role in long-term potentiation of memory

- polymorphism of genes may show impaired hippocampal activation and performance