Receptors Flashcards
What is a receptor
Proteins with variable degrees of complexity are sensitive to changes of the external and internal environments
Light receptors
Photoreceptors located on the eye register a to give a visual representation of the body surroundings
What happens when body is dehydrated
The hormone vasopressin is produced and binds to its receptor located on kidney nephron cells inducing the reabksrobtion of water in the bid
How do receptors work
A stimulus activates a receptor which activates an effector or effector system causing generation,propagation and multiplication of series of intercellular events leading to specific cellular events
What are the sensory receptors
Baroreceptors, mechanoreceptors, thermoreceptors, photoreceptors,some classified as nocirecpetord which are damage and pain receptors
Voltage-gated ion channels
A change in the membrane potentiL causes the protein to chnGe shape and open their activity can be modulated by drugs
What is a ligand
Is a substance that forms a complex with a receptor which will affect directly or indirectly a cellular activity - lock and key concept
What is lock and key concept
The interaction of ligand with its receptor binding site depends on many factors eg 3D structures electrostatic and hydrophocic interactions
Ligand-gated ion channels- receptors responsive to chemicals
are integral membrane proteins that contain a pore which allows the regulated flow of selected ions across the plasma membrane. Ion flux is passive and driven by the electrochemical gradient for the permeant ions.Eg neurotransmitter
Receptors with intrinsic enzymatic activity
Means that upon receptor activation they perform enzymatic reaction called phosphorylation on themselves and other proteins eg hormone insulin receptor
Intracellular/ nuclear receptor
Receptors for steroid ( testosterone) thyroid hormone vitamins D Internal receptors, also known as intracellular or cytoplasmic receptors, are found in the cytoplasm of the cell and respond to hydrophobic ligand molecules that are able to travel across the plasma membrane
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G protein-coupled receptors
7 transmembrane receptors for hormones: glucagon receptor
Nero transmitter Musca runic ACCESSh receptors extracellular nhcleotides atp p2y receptors G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that are located in the cell membrane, with their N- and C-termini located on the outer and inner surfaces, respectively. GPCRs mediate various cellular responses from the extracellular environmen