Reactions of COOH

Question 1

Rxns of COOH (5)

Answer 1

1. conversion to acid chlorides
2. conversion to esters
3. conversion to amides
4. reduction
5. conversion to acid anhydrides

Question 2

Conversion to acid chlorides

Answer 2

rgts: SOCl2, CHCl3
products: acid chloride, SO2, HCl

Question 3

Conversion into esters

Answer 3

via Sn2:
carboxylate + RX = ester
via acid catalyst:
COOH + ROH = ester + H2O

Question 4

Conversion into amides

Answer 4

rgts: RNH2, DCC
product: RCONHR

Question 5

Reduction

Answer 5

rgts: LiAlH4
product: primary OH

rgt: BH3/THF
product: primary OH

Question 6

Conversion to Acid Anhydrides

Answer 6

2 COOH undergo 800°C
product: 1 RCOOOR + H2O