Reactions of Acid Halides

Question 1

Hydrolysis

Answer 1

rgts: H2O
products: COOH + HCl

Question 2

Rxn with carboxylate

Answer 2

rgts: RCO2-
products: anhydride + Cl

with carboxylate salt: anhydride + NaCl

Question 3

Alcoholysis

Answer 3

rgts: ROH, pyridine
products: RCOOR + HCl

Question 4

Aminolysis

Answer 4

rgts: 2 NH3
products: RCONH2 + NH4Cl

Question 5

Reduction

Answer 5

rgts:
a. LiAlH4, ether and H3O+
b. NaBH4 and EtOH
products: primary OH

Question 6

Grignard rxn

Answer 6

rgts: RMgX, ether and H3O+
products: tertiary OH

Question 7

Diorganocopper rxn

Answer 7

rgts: R2CuLi (dialkylcuprate) and ether
products: ketones

Question 8

Acid chloride + xs ammonia, xs primary amine, xs secondary amine

Answer 8

ammonia: RONH2
primary amine: RONHR
secondary amine: RONR2

Question 9

Summary

Answer 9

Hydrolysis, rxns with carboxylates, alcoholysis, aminolysis, reduction, grignard rxn, diorganocopper